IMMUNOLOGY OF FOUR TROPICAL PARASITIC DISEASES OF MAN

热带病研究单位的这一计划项目建议研究四种 寄生虫病是发展中国家的地方病。 二、利什曼病 和南美锥虫病，是由原xoa和丝虫病， 血吸虫病是由蠕虫引起的。 目前的建议需要一个 免疫学方法来研究这些疾病。 重点放在描绘和分离抗原，诱导 使用淋巴细胞杂交产生的单克隆抗体的保护性免疫。 这些抗原将用于开发特定的诊断测试， 疫苗。 对保护性免疫机制的研究应有助于 后者的生产，以及免疫病理学的生产，应导致采取措施， 预防感染的后果。 在利什曼原虫项目中，重点是描绘物种特异性 新世界流行的生物体的抗原以及 不同种类的利什曼原虫与激活的人类巨噬细胞。 在 丝虫病项目，除了对阶段特异性抗原的研究， 免疫机制和免疫病理学，有相互作用的研究 有凝血因子和血小板的蠕虫 在锥虫体内 项目，细胞介导的免疫机制参与杀伤血液 溪流型T.克鲁兹很紧张。 在血吸虫病项目中， 被放置在研究的变化，表面上的龙童，导致 免疫逃避和那些由免疫攻击引起的;研究还 提出的机制嗜酸性粒细胞介导的杀死幼虫， 分离相关靶抗原。 电子显微镜的核心， 形态学，淋巴细胞杂交瘤，并维持生命周期， 包括.

This Program Project for a Tropical Disease Research Unit proposes study of four parasitic diseases that are endemic in the developing world. Two, leishmaniasis and South American trypanosomiasis, are caused by protoxoa, and filariasis and schistosomiasis are caused by helminths. The present proposal takes an immunologic approach to study of these diseases. Emphasis is placed on delineating and isolating the antigens which induced protective immunity using monoclonal antibodies produced by lymphocyte hybrids. These antigens will be used to develop specific diagnostic tests and eventually vaccines. Studies on the mechanism of protective immunity should aid in the production of the latter, and those on immunpathology should lead to measures to prevent the consequences of infection. In the leishmania project, an emphasis is placed on delineating species specific antigens from organisms prevalent in the New World and on the interaction of different species of leishmania with activated human macrophages. In the filariasis project, in addition to the studies on stage specific antigens and mechanism of immunity and immunopathology, there are studies on the interaction of worms with coagulation factors and platelets. In the trypanosomiasis project, the mechanism of cell-mediated immunity involved in killing blood stream forms of T. cruzi is stressed. In the schistosomiasis projects, emphasis is placed on studying changes on the surface of the schistosomula that lead to immune evasion and those that are caused by immune attack; studies are also proposed on the mechanism of eosinophil-mediated killing of the larvae, and on isolating relevant target antigens. Cores on electron microscopy and morphology, on lymphocyte hybridomas, and on maintaining the life cycles are included.