TROPICAL DISEASE RESEARCH UNITS

在过去的一年里，这个多学科计划项目的寄生虫 感染继续研究，旨在阐明致病性和调节 在以下领域建立机制：1. 在血吸虫病中， 嗜酸性粒细胞在宿主肉芽肿性反应中的功能。 曼氏菌卵的定义。 在缺乏这些细胞的情况下， 在宿主组织中引起相当大的发病率。 对S.日本 感染导致理解的过程中的病理生理调节 以及慢性感染小鼠疾病减少的潜在机制。 此外，特异性糖蛋白S. 日本血吸虫卵抗原 用于致敏肉芽肿形成和阐明 超敏反应已经被分离和表征。 2. 在贾第虫病中， 免疫力从母体被动转移到 他们的后代已经被描绘出来了 这些变化是由 给雌性老鼠注射性激素。 此外， 肠道的生物学和组织病理学变化。小鼠感染 研究了 3. 旨在确定相互作用的免疫学研究 巨噬细胞、淋巴细胞、血清携带因子和寄生虫， 有助于人体和实验动物的免疫应答及其调节 血吸虫病 在埃及和克利夫兰进行了研究， 抑制性脾细胞、对蠕虫抗原的免疫应答和单核细胞 介导的人血吸虫病童虫杀灭作用。 而且 激活的巨噬细胞增强的童虫杀伤机制已经被证实， 介绍了

During the past year, this multidisciplinary program project on parasitic infections continued studies aiming at elucidating the pathogenic and modulating mechanisms in the following areas: 1. In schistosomiasis, the protective function of the eosinophil within the host granulomatous response surrounding S. mansoni eggs has been defined. In the absence of these cells, eggs accumulate in the host tissues causing considerable morbidity. Studies on S. japonicum infection resulted in understanding the course of pathophysiological modulation and the underlying mechanism of decreased disease in chronically infected mice. Furthermore, the specific glycoprotein S. japonicum egg antigens responsible for sensitization for granuloma formation and elucidation of immediate hypersensitivity have been isolated and characterized. 2. In giardiasis, the dynamics and characteristics of immunity passively transferred from mothers to their offspring have been delineated. These changes were reproduced by injecting sex hormones in female mice. In addition, the localization of the organism and histopathologic changes in the intestines of G. muris infected mice were studied. 3. Immunologic investigations aimed at defining the interaction of macrophages, lymphocytes, serum borne factors and the parasites as they contribute to immune response and its regulation in human and experimental schistosomiasis. Studies were carried out in Egypt and Cleveland to evaluate the suppressor splenic cells, the immune response to worm antigens and monocyte mediated killing of schistosomula in human schistosomiasis. Furthermore, the mechanism of augmented schistosomula killing by activated macrophages have been described.