Expanding Capability and Capacity in High-Throughput Multinuclear NMR Spectroscopy

核磁共振波谱是研究分子结构和行为的一种基本方法。它是一种强大的工具，有助于确定纯化合物（在某些情况下甚至是化合物的混合物）的结构，提供对材料特性的洞察，并允许反应监测提供对化学反应机制的理解。核磁共振波谱仪和相关类型的核磁共振实验的多功能性使它们成为化学部门普遍存在的基本工具。化学家，地球化学家，材料和生命科学家需要快速和高通量的方法，从日益复杂的样品矩阵中提取定性和定量信息。这些测量（特别是需要分析痕量的应用）的一个关键要求是通过提高仪器灵敏度来降低检测极限。该提案将资助在现有的500 MHz核磁共振波谱仪（南安普顿化学核磁共振波谱小型研究设施的一部分）中安装一个新的低温冷却多核磁共振探针，从而创建一个新的高通量多核磁共振波谱仪。该仪器将为多核液体样品提供非常高的灵敏度和低检测限，特别是在检测杂原子方面，并将支持广泛的研究领域，包括催化，化学反应动力学和机制，合成有机化学，合成超分子化学，合成配位化学，合成生物学，地球化学，药物成像和化学生物学和生物化学。新的战略设备将支持整个南部地区的研究。来自区域合作伙伴（布里斯托尔大学、肯特大学、南安普顿大学和苏塞克斯大学）的科学将发展能力，随后扩展到其他学术和行业研究人员，形成一个卓越中心，以实现EPSRC的高优先级研究，并将补充EPSRC的全国设施。

Nuclear magnetic resonance (NMR) spectroscopy is a fundamental method that underpins the study of the structure and behaviours of molecules. It is a powerful tool that facilitates structure determination of pure compounds (and in some cases even of mixtures of compounds), offers insight into the characteristics of materials, and allows reaction monitoring to provide understanding of chemical reaction mechanisms. The versatility of NMR spectrometers and associated types of NMR experiments has made them essential tools that are ubiquitous in chemistry departments.Chemists, geochemists, materials and life scientists require rapid and high-throughput access to methods that extract both qualitative and quantitative information from increasingly complex samples matrices. A key requirement for these measurements (particularly applications requiring analysis of trace quantities) is a push to lower the limit of detection by increasing instrument sensitivity.This proposal will fund the installation of a new cryogenically-cooled multinuclear NMR probe into an existing 500 MHz NMR spectrometer (part of the Southampton Chemistry NMR spectroscopy Small Research Facility) creating a new high-throughput multinuclear NMR spectrometer. The instrument will provide very high sensitivity and a low limit of detection for multinuclear liquid samples, especially for detecting heteroatoms, and will underpin a broad range of research areas including Catalysis, Chemical Reaction Dynamics and Mechanisms, Synthetic Organic Chemistry, Synthetic Supramolecular Chemistry, Synthetic Coordination Chemistry, Synthetic Biology, Geochemistry, Medicinal Imaging and Chemical Biology and Biological Chemistry.The new strategic equipment will support research across the Southern region. The science from the regional partners (Universities of Bristol, Kent, Southampton and Sussex) will develop the capability and subsequently be extended to other academic and industry researchers to form a Centre of Excellence to enable high-priority EPSRC research and will complement EPSRC facilities nationally.