Control of allergic lung inflammation

澳大利亚是世界上哮喘发病率最高的国家之一。在这个项目中，我们将研究自然调节性T细胞如何在小鼠模型中抑制哮喘。我们将确定调节性T细胞和过敏性T细胞之间的相互作用发生的地点和时间，并确定调节性T细胞介导其抑制作用的机制。我们的发现将有助于理解哮喘发展的原因以及免疫系统本身如何控制哮喘。

Australia has one of the highest asthma rates in the world. In this project we will study how natural regulatory T cells suppress asthma in a mouse model. We will determine where and when interactions between regulatory T cells and allergic T cells occur, and define the mechanisms used by regulatory cells to mediate their suppressive effects. Our findings will aid in understanding why asthma develops and how it may be controlled by the immune system itself.