POST CORONARY ARTERY BYPASS GRAFT STUDY

该承包商将是一个临床中心， 试验，CABG（冠状动脉旁路移植术）后研究。 主 目的是观察通过药物治疗或 生活方式的改变（饮食、锻炼和戒烟）将 对长期（1年后）移植率有有益影响 再闭塞 CABG后将是一项随机临床试验， 有生物行为学和流行病学的研究。 的 生物行为研究部分的目的是确定 生物行为和心理社会因素，有助于成功的 CABG后调整。 流行病学研究部分的目的 是确定临床，生化和止血因素， 冠状动脉粥样硬化和移植物闭塞 附属 试验的目的包括评估干预措施对 (1)自体血管中冠状动脉粥样硬化的进展， 内乳移植物;（2）心室功能;（3）发病率和（4） 生活质量

This contractor will be a clinical center for the collaborative clinical trial, Post-CABG (Coronary Artery Bypass Graft) Study. The primary objective is to see if lowering serum cholesterol by drug treatment or by lifestyle modification (dietary, exercise, and cessation of smoking) will have a beneficial effect on the rate of long-term (after 1 year) graft reocclusion. Post-CABG will be a randomized clinical trial which will also have a biobehavioral component and an epidemiologic study component. The objective of the biobehavioral study component is to identify the biobehavioral and psychosocial factors that contribute to the successful adjustment after CABG. The objective of the epidemiologic study component is to identify clinical, biochemical and hemostatic factors that correlate with native coronary atherosclerosis and graft occlusion. Subsidiary objectives of the trial include assessing the effects of interventions on (1) progression of coronary atherosclerosis in the native vessels and internal mammary grafts; (2) ventricular function; (3) morbidity and (4) quality of life.