How age & sex impact the transcriptional control of mammalian muscle growth

保持健康的肌肉在生命的各个阶段都是至关重要的。衰老与肌肉的损失有关，由于基因表达和反应性的年龄相关变化，老年肌肉对生长有抵抗力。许多基因在男性和女性肌肉中的表达不同，这可能与肌肉生长和衰老的性别差异有关。该项目将产生关于哪些基因和生物学途径在决定哺乳动物肌肉大小和整个寿命和性别之间的生长方面至关重要的新知识。这些知识的应用可能会导致未来的方法，使健康的生活开始，促进澳大利亚人的健康老龄化，并对农业和肌肉作为食物来源产生影响。

Maintaining healthy muscle is crucial throughout all stages of life. Aging is associated with the loss of muscle and older muscles are resistant to growth due to age-related changes in gene expression and responsiveness. Many genes are expressed differently in male versus female muscle, which may have implications for sex-differences in muscle growth and aging. This project will generate new knowledge on which genes and biological pathways are crucial in determining mammalian muscle size and growth across the lifespan and between the sexes. Application of this knowledge may lead to future approaches to enable a healthy start to life and promote healthy aging in Australians and have implications for agriculture and muscle as a food source.