REVIEW AND ANALYSIS ON ENVIRONMENTAL MUTAGENESIS

本合同的目的是提供有关化学品的信息 基于数据的致突变、致分裂和遗传毒性 出版的文学作品。要做到这一点，一种化学物质的生物学特性 相关的代谢物、结构类似物和光学异构体将 已确认身份。此外，每种化学物质都将被检查是否存在 具有结构上的警觉性和亲电性。文学作品将会是 搜索有关致突变、致分裂和遗传毒性的信息 这些化学品的潜力和在化学品和 有助于理解分子机制的生物学文献 化学物质的诱变活性将被检索、评估和 在一份报告中总结。这些信息将有助于形成更好的 根据遗传毒性来理解化学物质的遗传毒性潜力 自身和相关化学品的影响。承包商将生产 每年五份报告各45份，但不超过60份 合同年。

The purpose of this contract is to provide information on a chemical's mutagenic, clastogenic, and genotoxic potential based on data in the published literature. To accomplish this, a chemical's biologically relevant metabolites, structural analogs, and optical isomers will be identified. In addition, each chemical will be examined for the presence of structurally alerting, electrophilic features. The literature will be searched for information on the mutagenic, clastogenic, and genotoxic potential of these chemicals and references in the chemical and biological literature that aid in understanding the molecular mechanism of the chemicals mutagenic activity will be retrieved, evaluated, and summarized in a report. This information will aid in forming a better understanding of a chemical's genotoxic potential based on the genotoxic effects of itself and related chemicals. The contractor will produce between 45 but no more than 60 reports per year for each of the five contract years.