CHRONIC TOXICITY STUDY OF D&C YELLOW 11

本研究将评价D & C Yellow #11通过在子宫内向F344大鼠施用该化合物。 这将通过在饮食中给予D & C Yellow #11来实现 浓度为0，500，1700或5000 ppm的雄性和 雌性F344大鼠。经过70天的化学暴露，这些F（O）父母 将交配，但将继续接受含有D & C黄的饮食 #11妊娠期和哺乳期。F（1）断奶仔猪从各自的 化学暴露组或对照组将被随机分配至治疗组 组，并继续接受含有D & C Yellow #11的饮食， 适合他们的群体，在他们的一生中。 暴露52周后，每组最多10只动物 尸检，保存所有组织并进行组织病理学处理。在 此外，在处死时，将从每只动物中采血 并评估一组血液学参数。 在暴露于含有D & C Yellow #11的饮食103周后，所有 对存活动物进行尸检，保存并处理所有组织 进行组织病理学检查和组织病理学评价。

This study will evaluate the carcinogenicity and chronic toxicity of D & C Yellow #11 by administering the compound in utero to F344 rats. This will be accomplished by administering D & C Yellow #11 in the diet at concentrations of 0,500, 1700, or 5000 ppm to groups of male and female F344 rats. After 70 days of chemical exposure these F(o) parents will be mated but will continue to receive diets containing D & C Yellow #11 during gestation and lactation. F(1) weanlings from the respective chemically exposed or control groups will be randomized into treatment groups and continue to receive diets containing D & C Yellow #11, at the concentration appropriate for their group, throughout their life time. After 52 weeks of exposure up to 10 animals per group will be necropsied, all tissues saved and processed for histopathology. In addition, at the time of sacrifice, blood will be drawn from each animal and a battery of hematological parameters evaluated. After 103 weeks of exposure to D & C Yellow #11 containing diets, all surviving animals will be necropsied, all tissues saved and processed for histopathology, and histopathologic evaluation conducted.