CHRONIC GAVAGE STUDY OF THEOPHYLLINE

根据这份合同进行的研究将评估致癌物质 茶碱对F344大鼠和B6C3F1小鼠的潜在作用。每组50只雄性 雌性F344大鼠将在玉米油中灌胃给予茶碱 7.5、25或75 mg/kg的剂量以及50只雄性或雌性小鼠组成的小组将 每周接受15、50或150 mg/kg的剂量，每周5天，共103周。在… 研究结束后将对幸存者进行尸检，收集所有组织并 进行了组织病理学检查和切片检查。

The study conducted under this contract will evaluate the carcinogenic potential of theophylline on F344 rats and B6C3F1 mice. Groups of 50 male and female F344 rats will receive theophylline by gavage in corn oil at doses of 7.5, 25, or 75 mg/kg and groups of 50 male or female mice will receive doses of 15, 50, or 150 mg/kg, 5 days per week for 103 weeks. At the end of the study survivors will be necropsied, all tissue collected and processed for histopathology and slides evaluated.