CHRONIC GAVAGE STUDY OF THEOPHYLLINE

根据该合同进行的研究将评估致癌性 茶碱对F344大鼠和B6 C3 F1小鼠的潜力。 每组50名男性 雌性F344大鼠将通过强饲法接受玉米油中的茶碱， 剂量为7.5、25或75 mg/kg，每组50只雄性或雌性小鼠， 接受15、50或150 mg/kg剂量，每周5天，持续103周。 在 研究结束时，将对存活动物进行尸检，采集所有组织， 进行组织病理学处理并评价切片。

The study conducted under this contract will evaluate the carcinogenic potential of theophylline on F344 rats and B6C3F1 mice. Groups of 50 male and female F344 rats will receive theophylline by gavage in corn oil at doses of 7.5, 25, or 75 mg/kg and groups of 50 male or female mice will receive doses of 15, 50, or 150 mg/kg, 5 days per week for 103 weeks. At the end of the study survivors will be necropsied, all tissue collected and processed for histopathology and slides evaluated.