Study on the chronic toxicity of organic solvents by the neurobehavioral test batteries

有机溶剂的神经毒性是职业健康领域最重要的新兴问题之一。本研究采用不同的中枢神经系统、周围神经传导速度、色觉和其他神经生理学检查方法，对接触苯乙烯和甲苯的日本工人进行了神经行为和心理影响的流行病学调查。神经行为测验、数字符号测验、圣安娜测验和词汇测验（同义词）两两比较，接触组明显低于对照组。累积暴露指数（CEI）> 18的工人神经行为表现明显低于工人。而CEI低于18（即50 ppm × 18岁）者的成绩与参照组无显著性差异。多元线性回归分析控制混杂变量，如年龄，酒精浓度， 关于我们 吸烟、吸烟习惯、文化程度、词汇量和数字广度测试结果显示，同义词得分与CEI显著相关，手眼运动协调和反应时与接触时间（年）显著相关。对79名苯乙烯作业男工和42名甲苯作业男工进行了色觉检查。苯乙烯暴露是由于玻璃增强聚酯材料的处理和照相凹版印刷过程中的甲苯暴露。采用标准化问卷调查，收集工作史，职业或非职业性溶剂暴露，饮酒和药物使用的数据。通过Lanthony去饱和板D-15测试评价色觉。测试结果表示为颜色混淆指数（CCI）。苯乙烯作业工人与年龄匹配的对照组之间存在显著性差异，而甲苯作业工人与对照组之间无显著性差异。大气中苯乙烯的平均暴露浓度约为20 ppm。扁桃酸平均尿浓度为0.43g/10.58。有一个显着差异CCI之间的接触工人和年龄匹配的对照组。尿扁桃酸浓度为0.42g/l的工人与尿扁桃酸浓度为0.42g/l的工人相比，色觉明显受损。多元线性回归分析，控制混杂变量，如年龄，饮酒，吸烟，教育程度表明，CCI是显着相关的扁桃酸浓度。在暴露工人和对照组中，缺陷类型大多是蓝黄色的损失，虽然少数受试者表现出复杂的损失。没有人表现出红绿相间的损失。少

The neurotoxicity of organic solvents is one of the most important emerging issues in the field of occupational health. We conducted several epidemiological survey on the neurobehavioral and psychological effects using different kind of tests for central nervous system, neuroconduction velocity of peripheral nerves, color vision and other neurophysiological tests among Japanese workers who have been exposed to stirene and toluene. The results of pairwise comparison of the neurobehavioral test, performance on the digit symbol test, Santa Ana test and vocabulary test (synonyms) in exposed subject were significantly lower than those of workers. Neurobehavioral performance of those whose cumulative exposure index (CEI) was above 18 was significantly lower than those of Workers. But performance whose CEI was lower than 18 (i.e.50ppm x 18years) not significant with those of the referent group. Multiple linear regression analysis controlling for confounding variables such as age, alcohol cons … More umption, smoking habit, education attainment, vocabulary and digit span tests showed that the synonym score were significantly related to the CEI.Both hand-eye motor coordination and reaction time were also significantly related to exposed duration (years). Color discrimination was examined in 79 male workers exposed to stirene and in 42 workers exposed to toluene. Stirene exposure was due to the handling of glass-reinforced polyester materials and toluene exposure in the photogravure printing process. A standardized quesionnaire was adopted to collect work history, data on occupational or nonoccupational solvent exposure, alcohol consumption and drug use. Color vision was evaluated by the Lanthony desaturated panel D-15 test. The results of the test were expressed as the color confusion index (CCI). A significant difference was found between stirene-exposed workers and age-matched referents but not in the study of workers exposed to toluene and their referents. The mean atmospheric stirene exposure concentration was about 20 ppm. The mean urinary concentration of mandelic acid was 0.43g/1 0.58. There was a significant difference in CCI between exposed workers and age-matched controls. Color vision of workers whose concentration of urinary mandelic acid was 0.42g/1 was significantly impaired when compared with workers whose concentration was 0.42g/1. Multiple linear regression analysis that controlled for confounding variables such as age, alcohol consumption, smoking, and educational attainment showed that CCI was signifcantly related to the concentration of mandelic acid. In both exposed workers and controls, the types of defects were mostly blue-yellow loss, although a few subjects showed complex loss. no one showed red-green loss. Less