Study on the chronic toxicity of organic solvents by the neurobehavioral test batteries

有机溶剂慢性毒性的神经行为测试电池研究

• 批准号: 08457135
• 负责人: MIYAKE Hirotsugu
• 金额: $ 3.58万
• 依托单位: SAPPORO MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457135/
• 关键词: neurobehavioral tests; neuropsychological effects; organic solvents; chronic exposure; neuroconduction velocity; color vision; toluene; stirene; 精神神経障害; 末梢神経伝導速度; 色覚

The neurotoxicity of organic solvents is one of the most important emerging issues in the field of occupational health. We conducted several epidemiological survey on the neurobehavioral and psychological effects using different kind of tests for central nervous system, neuroconduction velocity of peripheral nerves, color vision and other neurophysiological tests among Japanese workers who have been exposed to stirene and toluene. The results of pairwise comparison of the neurobehavioral test, performance on the digit symbol test, Santa Ana test and vocabulary test (synonyms) in exposed subject were significantly lower than those of workers. Neurobehavioral performance of those whose cumulative exposure index (CEI) was above 18 was significantly lower than those of Workers. But performance whose CEI was lower than 18 (i.e.50ppm x 18years) not significant with those of the referent group. Multiple linear regression analysis controlling for confounding variables such as age, alcohol cons … More umption, smoking habit, education attainment, vocabulary and digit span tests showed that the synonym score were significantly related to the CEI.Both hand-eye motor coordination and reaction time were also significantly related to exposed duration (years). Color discrimination was examined in 79 male workers exposed to stirene and in 42 workers exposed to toluene. Stirene exposure was due to the handling of glass-reinforced polyester materials and toluene exposure in the photogravure printing process. A standardized quesionnaire was adopted to collect work history, data on occupational or nonoccupational solvent exposure, alcohol consumption and drug use. Color vision was evaluated by the Lanthony desaturated panel D-15 test. The results of the test were expressed as the color confusion index (CCI). A significant difference was found between stirene-exposed workers and age-matched referents but not in the study of workers exposed to toluene and their referents. The mean atmospheric stirene exposure concentration was about 20 ppm. The mean urinary concentration of mandelic acid was 0.43g/1 0.58. There was a significant difference in CCI between exposed workers and age-matched controls. Color vision of workers whose concentration of urinary mandelic acid was 0.42g/1 was significantly impaired when compared with workers whose concentration was 0.42g/1. Multiple linear regression analysis that controlled for confounding variables such as age, alcohol consumption, smoking, and educational attainment showed that CCI was signifcantly related to the concentration of mandelic acid. In both exposed workers and controls, the types of defects were mostly blue-yellow loss, although a few subjects showed complex loss. no one showed red-green loss. Less

有机溶剂的神经毒性是职业健康领域最重要的新问题之一。我们通过不同类型的中枢神经系统测试、周围神经传导速度、色觉和其他神经生理学测试，对接触苯乙烯和甲苯的日本工人进行了多项神经行为和心理影响的流行病学调查。暴露对象的神经行为测试、数字符号测试、圣安娜测试和词汇测试（同义词）的两两比较结果均显着低于工人。累积暴露指数（CEI）大于18的人的神经行为表现明显低于工人。但 CEI 低于 18（即 50ppm x 18 年）的表现与参照组的表现并不显着。控制年龄、酗酒、吸烟习惯、教育程度、词汇量和数字跨度测试等混杂变量的多元线性回归分析表明，同义词得分与 CEI 显着相关。手眼运动协调性和反应时间也与暴露时间（年）显着相关。对接触苯乙烯的 79 名男性工人和接触甲苯的 42 名工人进行了颜色歧视检查。苯乙烯暴露是由于玻璃增强聚酯材料的处理和照相凹版印刷过程中的甲苯暴露造成的。采用标准化调查问卷来收集工作经历、职业或非职业溶剂接触、饮酒和吸毒数据。色觉通过 Lanthony 去饱和面板 D-15 测试进行评估。测试结果以颜色混淆指数（CCI）表示。在接触苯乙烯的工人和年龄匹配的参考对象之间发现了显着差异，但在接触甲苯的工人及其参考对象的研究中没有发现显着差异。平均大气苯乙烯暴露浓度为约20 ppm。扁桃酸的平均尿浓度为0.43g/1±0.58。暴露工人和年龄匹配的对照组之间的 CCI 存在显着差异。尿扁桃酸浓度为0.42g/1的工人色觉较0.42g/1浓度的工人显着受损。控制了年龄、饮酒、吸烟和教育程度等混杂变量的多元线性回归分析表明，CCI 与扁桃酸的浓度显着相关。在暴露的工人和对照组中，缺陷类型大多是蓝黄色损失，尽管少数受试者表现出复杂的损失。没有人表现出红绿损失。较少的

项目成果

Yuasa J,Eguchi T,Harabuchi I,Arata Y,Katakura Y,Imai T,Matsumoto H,Yokoyama H,Miyake H: "Study of Urinary Mandelic Acid Concentration and peripheral Nerve Conduction Among Styrene Workers" American Journal of Industrial Medicine. 30. 41-47 (1996)

Yuasa J、Eguchi T、Harabuchi I、Arata Y、Katakura Y、Imai T、Matsumoto H、Yokoyama H、Miyake H：“苯乙烯工人尿扁桃酸浓度和周围神经传导的研究”美国工业医学杂志。

Yuasa J,Kishi R,Eguchi T Harabuchi I,Kawai T.et al: "Investigation on neurotoxicity of occupational exporure to cyclohezane : aneurophysiological study" Occupational and Environmental Medicine. 53巻. 174-179 (1996)

Yuasa J、Kishi R、Eguchi T Harabuchi I、Kawai T. 等人：“职业接触环己烷的神经毒性调查：神经生理学研究”职业和环境医学。 53. 174-179 (1996)

Yuasa J,Kishi R,Eguchi T,Harabuchi I,Arata Y,etal.: "Study of Urinary Mandelic acdi Concertration and Peripheral Nerve Conduction Among Styrene Workers" American Journal of Industrial Medicine. 30巻. 41-47 (1996)

Yuasa J、Kishi R、Eguchi T、Harabuchi I、Arata Y 等人：“苯乙烯工作者中尿扁桃酸协调和周围神经传导的研究”美国工业医学杂志 30. 41-47 (1996)。

Kishi R.: "Reseach Methods of exposure-effect assessment in industry-From to epidemiological study." Science of labor. 52(1). 50-54 (1997)

Kishi R.：“工业中暴露效应评估的研究方法——从流行病学研究。”

Yuasa J,Eguchi T,Harabuchi I,Kawai T,Ikeda M,Sugimoto R,Matsumoto H,Miyake H: "Investigation on neurotoxicity of occupational exposure to cyclohexane:a neurophysiological study" Occupational and Environmental Medicine. 53. 174-179 (1996)

Yuasa J，Eguchi T，Harabuchi I，Kawai T，Ikeda M，Sugimoto R，Matsumoto H，Miyake H：“职业接触环己烷的神经毒性调查：一项神经生理学研究”职业与环境医学。