CHRONIC STUDIES OF BUTYL BENZYL PHTHALATE

根据这份合同进行的研究将评估 邻苯二甲酸丁基苄酯的毒性和致癌性 在饮食中给药两年的男性和女性F344 大鼠和B6C3F1小鼠。此外，这些研究将评估 体重增加减少对大鼠肿瘤发病率的影响。 这将通过喂食特殊群体的老鼠和 将其体重维持在以下的饲料量 那些随意喂养动物的人。所有濒临死亡的动物，以及 那些存活到研究结束的人将获得 完成大体检查。所有肉眼可见的损伤和所有 含有非肿瘤性或肿瘤性病变的组织 与化学物质接触的人会接受完整的组织病理学检查 考试。

The studies to be conducted under this contract will evaluate the toxicity and carcinogenicity of butylbenzyl phthalate administered in the diet for two years to male and female F344 rats and B6C3F1 mice. In addition, these studies will evaluate the effect of reduced weight gain on tumor incidence in rats. This will be accomplished by feeding special groups of rats an amount of feed which will maintain their body weights below that of the ad lib fed animals. All moribund animals, as well as those that survive to the end of the study, will receive a complete gross examination. All grossly visible lesions and all tissues containing non-neoplastic or neoplastic lesions associated with chemical exposures will receive a complete histopathologic examination.