Polymer-[2]rotaxane molecular shuttles: a new class of non-covalent mechanophore for sensing cell forces

到2035年，欧洲每年的癌症诊断将增加到430多万，使其成为第二大死亡和发病原因。“地平线欧洲”的“癌症使命”旨在到2030年拯救300万人的生命，因此建立癌症早期诊断的新策略至关重要。该项目的主要目标是开发一种新的分子探针，用于检测转移性癌症的关键标志物：由不受控制的细胞分裂产生的机械力。为了实现这一目标，该项目汇集了聚合物机械化学专家Sharma博士（研究员）和光活性分子机器专家Barendt博士（主持人）。该项目为团队提供了一个及时的机会，以填补当前对生物传感机械载体的需求。该项目将为生物学家和临床医生提供最先进的传感器，用于早期诊断癌症。该项目将学员和东道主的专业知识结合起来，为整个项目提供双向知识转移的机会。对于研究员来说，科学和可转移技能方面的具体培训目标将使他们能够实现下一个职业目标：领导生物传感用有机材料的独立研究项目。项目工作计划（工作包、任务）和已建立的支持团队（科学的、可转移的技能）将确保所有研究和培训目标的实现。

Annual cancer diagnoses in Europe will increase to more than 4.3M by 2035, making it the second most important cause of death andmorbidity. The Horizon Europe 'Cancer mission' aims to save 3 million lives from cancer by 2030, making it critical that new strategiesfor the early diagnosis of cancer are established. The primary objective of this project is to develop a novel molecular probe fordetecting a key marker of metastatic cancer: the mechanical forces that arise from uncontrolled cell division. To realisethis, the project brings together Dr Sharma (Fellow), an expert in polymer mechanochemistry, and Dr Barendt (Host), an expert inphoto-active molecular machines. This project presents a timely opportunity for the team to fill the current need for mechanophoresfor bio-sensing. This project will arm biologists and clinicians with a state-of-the-art sensor for diagnosing cancer at an early-stage.The project synergises Fellow and Host expertise, providing opportunities for two-way knowledge transfer throughout theprogramme. For the Fellow, specific training objectives in scientific and transferable skills will enable them to realise their next careergoal: leading an independent research programme in organic materials for bio-sensing. The project work plan (work packages, tasks) and established support team (scientific,transferable skills) will ensure all research and training objectives are realised.