WOMEN AND INFANTS TRANSMISSION STUDY (WITS II)

妇女和婴儿传播研究（WITS-II）将招募 艾滋病病毒感染孕妇及其婴儿进入一个多中心， 流行病学队列研究，其目的是回答关键的 与怀孕期间艾滋病毒疾病有关的问题，以及 母婴传播 此外，研究问题 与实施治疗干预有关， 人口将得到解决。 WITS II的具体目标是： 评估妊娠对孕产妇艾滋病毒进展的影响2） 确定与垂直传播有关的母体辅助因素 3)评估感染婴儿的早期诊断技术 4)描述感染者的HIV疾病的自然史 5）评估疫苗试验的可行性， 人口 WITS II是目前资助的一项研究的延续 (WITS（一）。 它将利用核心WITS I协议沿着 根据当前知识水平进行适当修改， 收集流行病学、医学和实验室数据。 专用 标本库将提供独特的样本， 创新的早期诊断技术以及用于 最先进的实验室技术， 问题.

The Women and Infants Transmission Study (WITS-II) will enroll HIV-infected pregnant women and their infants into a multicenter, epidemiologic cohort study whose objectives are to answer critical questions relevant to HIV disease during pregnancy, and maternal-infant transmission. In addition, research issues relevant to implementation of therapeutic intervention in this population will be addressed. The specific aims of WITS II are 1) to assess the effects of pregnancy on maternal HIV progression 2) to determine maternal co-factors related to vertical transmission 3) to evaluate techniques for early diagnosis of infected infants 4) to describe the natural history of HIV disease in infected infants and 5) to assess the feasibility of vaccine trials in this population. WITS II is a continuation of a currently funded study (WITS I). It will utilize core WITS I protocols along with modifications appropriate to the current state of knowledge to gather epidemiologic, medical, and laboratory data. A dedicated specimen repository will provide unique samples for evaluation of innovative early diagnostic techniques as well as for utilization of state of the art lab techniques in answering key research questions.