PEDIATRIC AIDS CLINICAL TRIALS UNIT

芝加哥儿科艾滋病临床试验中心招募了134名患者 在艾滋病临床试验小组的四年中 存在。大多数患者都参加了治疗方案 中国艾滋病不同阶段的抗逆转录病毒治疗评价 孩子们。我们对第一阶段/第二阶段协议特别感兴趣，因为 我们有能力以五种方案招募30名患者，这就是明证。至 增加感染艾滋病毒的孕妇在围产期的参与度 协议，我们提议在华盛顿大学设立一个子单位 伊利诺伊州进行妇女/儿童传播研究(WITS) 芝加哥。目前成功招聘和留住智者的努力 感染艾滋病毒的孕妇确保了这些人的入学人数增加 妇女参加围产期研究。我们的目标也是参与协议 涉及机会性感染和基于免疫治疗的评价 包括疫苗。拟议的芝加哥财团的四个单元 位于城市的不同地方，这将帮助我们 有效地接触到大多数已知受艾滋病影响的家庭 芝加哥的流行病。我们还申请了资金，以建立一个 病毒学和免疫学部分，将解决 儿科ACTG方案。此外，还要求提供资金以实现 美国将参与儿科ACTG的药理学方面 协议。我们正在申请资金，以支持我们招生的努力 每年在ACTG方案中新增70名患者，2)转移8名患者 在其原始议定书完成后，每年向新议定书提供资金。在……里面 此外，所要求的资金将确保顺利继续 对94名已经参与ACTG方案的患者进行随访。 在申请的C部分，我们要求为发展研究提供资金 病毒学(C-1)、免疫学(C-2)和神经心理学评估 (C-3)

The Chicago Pediatric AIDS Clinical Trials Unit has enrolled 134 patients in AIDS Clinical Trials Group Protocols during its four years of existence. Most of the patients have been enrolled in protocols evaluating antiretroviral therapy in different stages of HIV disease in children. We have a special interest in phase I/II protocols as evidenced by our ability to enroll 30 patients in five protocols. To increase participation of HIV-infected pregnant women in perinatal protocols, we are proposing to establish a subunit at the University of Illinois which conducts the Women/Children Transmission Study (WITS) in Chicago. The current successful efforts of WITS to recruit and retain HIV-infected pregnant women assures an increase in enrollment of these women to perinatal studies. Our goal is also to participate in protocols involving opportunistic infections and evaluation of immune-based therapy including vaccines. The proposed four units of the Chicago consortium are located in different parts of the city which will help us to effectively reach most of the families known to be affected by the AIDS epidemic in Chicago. We have also applied for funds to establish a virology and immunology component which will address questions unique to the pediatric ACTG protocols. In addition, funds are requested to enable us to participate in the pharmacological aspects of the Pediatric ACTG protocols. We are applying for funds to support our efforts 1) to enroll 70 new patients per year in ACTG protocols and 2) to transfer 8 patients per year to new protocols upon completion of their original protocol. In addition, the requested funds will assure a smooth continuation of followup on 94 patients who are already participating in ACTG protocols. In part C of the application we request funds for developmental research in virology (C-1), immunology (C-2) and neuropsychological assessment (C-3).