NOCTURNAL ASTHMA--INCREASED BRONCHIAL RESPONSIVENESS

这笔拨款的整体目的是加深我们对 夜间哮喘的恶化与昼夜节律性增加有关 夜间的支气管反应性。这将使更好地 基于特定知识的治疗干预措施 这种高频率和高发病率的实体。实现这一目标的方法 Goal将专注于细胞、神经和结构的变化 航空公司在昼夜节律的基础上。这些方面将与 呼吸道的生理功能。具体的实验设计 将会是： 1.测量并机械改变睡眠时的肺体积，以确定 肺容量/阻力关系及改变肺容量的影响 炎症、迷走神经张力和支气管反应性。 2.通过减少呼吸道炎症来确定炎症的作用 细胞密度，对支气管反应性和相互作用 炎症对容量和迷走神经张力的影响。 3.测量和阻断迷走神经张力是夜间哮喘的另一个因素 并增加了对支气管的反应性。 4.测定呼吸道(支气管内膜)的形态变化 活组织检查)及其与肺容量、气道改变的关系 阻力、呼吸道炎症、迷走神经张力和支气管反应性。

The overall objective of this grant is to further our understanding of the nocturnal worsening of asthma in regard to the circadian increase in bronchial responsiveness during the night. This will enable better therapeutic interventions, based upon specific knowledge, for the treatment of this high frequency and morbidity entity. The methods of achieving this goal will focus on cellular, neural and structural changes within the airways on a circadian basis. These aspects will be correlated to the physiologic functioning of the airways. The specific experimental designs will be: 1. To measure and mechanically alter lung volume during sleep to determine the volume/resistance relationship and the effect of changing lung volume on inflammation, vagal tone and bronchial responsiveness. 2. To determine the role of inflammation by decreasing the airways cellularity, on bronchial responsiveness and the interaction of inflammation to volume and vagal tone. 3. To measure and block vagal tone as another factor of nocturnal asthma and increased bronchial responsiveness. 4. To determine the morphologic changes in the airways (endobronchial biopsies) and its relationship to changes in lung volume, airways resistance, airways inflammation, vagal tone and bronchial responsiveness.