PREVENTION OF OSTEOPOROSIS AND NEPHROLITHIASIS DURING BEDREST WITH ABD

这项研究的总体目标是确定是否使用 氨基羟丁基二磷酸盐(ABD)可以阻止这种发展。 高钙尿症、高磷尿症、钙负平衡和 成石钙的结晶倾向增加 长期卧床的正常受试者的盐分。这个项目将 验证ABD可以预防骨质疏松症和 太空飞行中抑制骨吸收导致的肾结石， 采用卧床固定模式。

The overall goal of this study is to determine if treatment with aminohydroxybutylidine diphosphonate (ABD) would avert the development of hypercalciuria, hyperphosphaturia, negative calcium balance and increased propensity for the crystallization of stone-forming calcium salts in normal subjects undergoing prolonged bedrest. This project will test the hypothesis that ABD could prevent osteoporosis and nephrolithiasis during space flight by inhibiting bone resorption, utilizing the model of bedrest immobilization.