课题基金 / 基金详情

CANDIDATE GENES WITH TRIMERIC REPEATS IN NEUROPSYCHIATRY

CANDIDATE GENES WITH TRIMERIC REPEATS IN NEUROPSYCHIATRY
神经精神病学中具有三聚体重复的候选基因
批准号：
2240472
负责人：
MELVIN G MCINNIS
金额：
$12.42万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-05-01 至 1999-04-30
来源：
https://reporter.nih.gov/project-details/2240472
关键词：
bipolar depression computer assisted sequence analysis family genetics gene expression genetic library genetic markers genetic polymorphism human genetic material tag human tissue linkage mapping molecular cloning neuropsychology nucleic acid repetitive sequence polymerase chain reaction

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相关文献

中文摘要
翻译
我的研究计划是由一个普遍的假设驱动的， 三核苷酸重复序列（TNR）在大脑中表达， 它们在膨胀时会导致神经精神疾病已知 含有TNR的基因通常是多态的， 作为连锁标记的价值。我的研究进展 该计划建立在我目前的连锁映射技能和扩展 用于基因克隆和表达分析。 我的长期职业生涯 计划是识别、表征和研究与癌症相关的基因， 精神病 我将鉴定和表征含有TNR的cDNA克隆， 我将绘制这些重复序列并检查双相情感障碍 家庭成员的扩张证据。
英文摘要
My research plan is driven by the general hypothesis that genes with trinucleotide repeats (TNRs) are expressed in brain and when they under expansion, cause neuropsychiatric disease. It is known that genes containing TNRs are frequently polymorphic and are to that extent valuable as linkage markers. My research development plan builds on my present skills of linkage mapping and extends them to gene cloning and expression analysis. My long term career plans are to identify, characterize and study genes involved with psychiatric disease. I will identify and characterize cDNA clones containing TNRs and will map these repeats and examine bipolar affective disorder family members for evidence of expansion.
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