DEVELOPMENTAL PHYSIOLOGY OF KIDNEY AND URINARY TRACT

这个“儿科卓越研究中心”的总体目标 肾病学和泌尿学》是提供一个协调的、跨学科的 和多机构方法进行研究，试图澄清 胎儿和胎儿肾脏和尿路功能的调节机制 后天发育。这个研究中心的主题是 肾和尿路功能的神经化学控制的个体发生学 在正常和病态的情况下。 用于实现这一总体目标的是董事会，范围从关于 整合生理学研究的分子和细胞机制 和神经生理现象。 项目1和2涉及交感神经系统和 肾上腺素能系统在早期调节体液平衡中的作用 发展。更具体地说，项目1将调查个体发育 胎儿肾交感神经活动调节机制的研究进展 以及出生后的生活。项目2将测试不同的假设 多肽激素对肾上腺素能受体和受体后受体的影响 成熟过程中的机制。项目3将提供对 调节肾素生物合成、转运和代谢的分子过程 由发育中的肾脏释放。项目4将使用分子生物学 和综合生理学方法来检验ANP的假设 在发育早期调节钠稳态，并在 发育中的肾脏对单侧输尿管的适应性 障碍物。研究中心将由两个核心支持 设施：行政和教育。 研究项目与历史的密切主题关系 调查人员之间富有成效的合作代表着一种独特的 扩大我们的知识并获得新的和重要的机会 关于调节肾脏发育的机制和 尿路。

The overall objective of this "Research Center of Excellence in Pediatric Nephrology and Urology" is to provide a coordinated, interdisciplinary and multi-institutional approach to studies seeking to elucidate mechanisms regulating renal and urological function during fetal and postnatal development. The main theme of this Research Center is "Ontogeny of Neurochemical Control of Renal and Urological Function during Normal and Pathological Conditions." The approaches that will be used to achieve this general objective are board, ranging from studies on molecular and cellular mechanisms to integrate studies of physiological and neurophysiological phenomena. Projects 1 and 2 involve the role of the sympathetic nervous system and adrenergic system in modulating body fluid homeostasis during early development. More specifically, Project 1 will investigate the ontogeny of mechanisms regulating renal sympathetic nerve activity during fetal and postnatal life. Project 2 will test the hypothesis that different peptide hormones influence renal adrenergic receptors and post-receptor mechanisms during maturation. Project 3 will provide new insight into the molecular processes regulating renin biosynthesis, trafficking and release by the developing kidney. Project 4 will use molecular biology and integrative physiology approaches to test the hypothesis that ANP mediates sodium homeostasis early during development and plays a role in the adaptation of the developing kidney to unilateral ureteral obstruction. The Research Center will be supported by two core facilities: Administration and Education. The close thematic relation of the research projects and the history of productive collaboration between investigators represent a unique opportunity to expand our knowledge and to obtain new and important information on mechanisms regulating the development of the kidney and urinary tract.