Cortictropin releasing factor as a therapeutic target for alcohol and drug abuse

酒精中毒的一个关键问题，就像成瘾一样，是这种疾病的慢性复发性。这可以在啮齿动物中建模，并且在动物复吸研究和人类复发经验之间存在良好的一般对应性。我们已经确定了参与这一过程的大脑化学物质。因此，通过更好地了解与成瘾和复发有关的生物学机制，我们将能够对抗这种毁灭性的状况。

A key problem with alcoholism, as with addiction generally, is the chronically relapsing nature of the disorder. This can be modelled in rodents and there is good general correspondence between animal studies of reinstatement and human experience of relapse. We have identified brain chemicals involved in this process. Consequently, by better understanding the biological mechanisms related to addiction and relapse, we will be in a position to counter this devastating condition.