BIOBEHAVIORAL STUDIES OF CARDIOVASCULAR DISEASE

项目1的主要目标是检验个人 行为诱发的心血管反应性的差异是 与动脉粥样硬化及左冠状动脉指数呈正相关 既往未经治疗的高血压患者的脑室扩大。其中 该项目的具体目标是确定：(A)是否 血流动力学调节的大小和模式的可变性 由行为刺激(压力)引起的压力与 颈动脉粥样硬化和/或左侧增厚的证据 高血压患者的心脏重量；。(二)是否如此。 非裔美国人和非裔美国人之间的关系在性质上不同 高加索人高血压；及(C)是否存在个体差异 心血管反应性与心理社会因素的关系 (例如，愤怒/敌意；社会支持)动脉粥样硬化或左撇子 高加索人和非裔美国人的心脏质量。我们 建议招募400名临界和轻度高血压男性，定义为 收缩压在140至180毫米汞柱之间。待收集的数据 对每个患者的影响包括：(A)对一系列药物的心血管反应 行为(认知、精神运动和人际)挑战；(B) 颈动脉疾病的超声测量；(C)超声心动图 测量左心室结构和功能，以及 血管顺应性的非侵入性评估；(D)心理社会因素 曾与高血压或冠心病有关；及(3) 心血管疾病的几个已知或假定的危险因素(例如， 空腹胰岛素，血脂浓度，动态血压， 心血管疾病关系的首次系统研究 对动脉粥样硬化和左心室重量的反应性 未合并既往治疗的双胎高血压样本。 其次，这项研究将提供重要的新信息， 在心脏形态、血管顺应性、 颅外颈动脉疾病和应激反应， 以及这些参数与心理社会因素的关系 对心血管疾病具有潜在的意义。

The principal aim of Project 1 is to test the hypothesis that individual differences in behaviorally evoked cardiovascular reactivity are associated positively with atherosclerosis and indices of left ventricular enlargement among previously untreated hypertensives. Among the specific objectives of this project are to determine: (a) whether variability in the magnitude and patterning of hemodynamic adjustments induced by behavioral stimuli (stress) are associated with extent of carotid artery atherosclerosis and/or evidence of increased left ventricular mass among hypertensive individuals; (b) whether such relationships vary in nature of magnitude between African-American and Caucasian hypertensive; and (c) whether individual differences in cardiovascular reactivity mediated relationships of psychosocial factors (e.g., anger/hostility; social support) with atherosclerosis or left ventricular mass among Caucasian and African-American individuals. We propose to recruit 400 borderline and mild hypertensive men, defined by systolic blood pressure between 140 and 180 mm Hg. Data to be collected on each patient include: (a) cardiovascular responses to a battery of behavioral (cognitive, psychomotor and interpersonal) challenges; (b) ultrasound measurements of carotid artery disease; (c) echocardiographic measurements of left ventricular structure and function, as well as noninvasive evaluations of vascular compliance; (d) psychosocial factors previously implicated in hypertension or coronary disease; and (3) several known or putative risk factors for cardiovascular disease (e.g., fasting insulin, serum lipid concentrations, ambulatory blood pressure, the first systematic study of the relationship of cardiovascular reactivity to both atherosclerosis and left ventricular mass in a biracial hypertensive sample uncomplicated by prior treatment. Secondarily, this study will provide important new information regarding racial differences in ventricular morphology, vascular compliance, extracranial carotid artery disease and hemodynamic reactions to stress, as well as the relationship of these parameters to psychosocial factors of potential significance for cardiovascular disease.