Intelligent Breast Cancer DiagnOsis and MonItoring Therapeutic Response Training Network (CanDoIt)

CanDoIt将展示用于液体活检分析的与DNA寡核苷酸及其肽核酸（PNAs）类似物相关的智能多模态多物理传感器阵列如何通过研究生物/纳米材料、传感器和传感器设计、流体系统和人工智能方面的前沿技术，具有更准确诊断和治疗BC的潜力。CanDoIt的目标是：(1)培养优秀的下一代研究人员，从事基础，应用，特别是转化BC研究的跨学科职业，并“提高对社会问题的认识”；(2)通过汇集业界和学术界的知名专家，包括工程师、计算科学家、化学家、物理学家和临床医生，开发BC诊断和监测治疗反应的前沿技术；(3)通过智能方法追求关键生物学靶点，从早期到临床前和临床研究；(4)除了应对BC问题外，所提出的智能生物系统将是一个真正的技术进步（突破），这要归功于不同传感器的联合走向多模态平台，受生活世界启发的结构化纳米材料的联合以及智能算法的实施进行优化分析；(5)构建高影响力结构，确保所有成果的多层次传播和利用。

CanDoIt will show how a smart multimodal multi-physic sensor array associated with DNA oligonucleotides and their peptide nucleic acid (PNAs) analogues dedicated for liquid biopsies analysis has the potential for more accurate diagnostic and treatment monitoring of BC through the study of cutting-edge technologies in bio/nanomaterials, sensors and transducers design, fluidics systems, and artificial intelligence. The CanDoIt objectives are to: (1) Train the excellent next generation researchers for interdisciplinary careers in basic, applied and especially translational BC research and with "raising awareness" on social issues; (2) Develop cutting-edge technologies for BC diagnosis and monitoring therapeutic response by bringing together eminent experts from both industry and academia, including engineers, computational scientists, chemists, physicists, and clinicians; (3) Pursue key biological targets through intelligent methods, all the way from early stage to preclinical and clinical investigation; (4) In addition to respond to the BC issue, the intelligent biosystems proposed will be a real technological advance (breakthrough), thanks to the association of different transducers to go towards a multimodal platform, the association of structured nanomaterials inspired by living world and an implementation of intelligent algorithms for optimal analysis; (5) Build a high-impact structure ensuring multi-level dissemination and exploitation of all results.