Identifying mechanisms and novel treatments of bone pain - closing the gap to the clinic. BonePainIII

在欧盟，肌肉骨骼疾病是导致严重长期疼痛的最常见原因，并导致重大的医疗保健和社会支持成本。患病率随着年龄的增长而增加，由于肥胖和缺乏体育活动等生活方式因素导致个人寿命增加，骨骼健康状况下降，预计未来几十年个人和社会的骨痛负担将进一步增加。众所周知，骨痛很难用现有的止痛药治疗，因此对基于机制的治疗有很大的需求。因此，培养高技能的研究人员以促进骨痛领域的前沿研究、创新和教育是相关的。在BonePainIII中，我们汇集了3个工业受益者，4个学术受益者，2个工业合作伙伴和3个学术合作伙伴，在一个高度跨学科和跨部门的网络中，包括生物工程，神经科学，药理学，药物发现和临床医学。BonePainIII将培养新一代的10名创新、创业和创新的早期研究人员（ESR），他们将在博士课程中获得具体的研究和可转移的能力。可转移技能项目由讲习班和课程组成，涵盖了在学术或非学术领域取得成功的基本技能，包括创业、知识转移、开放科学、编码和人工智能、沟通、自我营销、外展、知识产权和环境实践。致力于主办可持续发展研究和通过借调和讲习班进行培训的非学术部门的大力参与，确保可持续发展研究将接触到学术界和工业界，一个性别平衡的监督小组将消除与性别有关的障碍。两大障碍阻碍了骨痛药物的发现：1)缺乏对骨痛潜在分子和细胞机制的理解；2)临床转化的差距。在BonePainIII中，我们将通过四个综合的、雄心勃勃的、可实现的研究工作包来应对这些挑战。

Musculoskeletal conditions are the most common cause of severe long term pain in the EU and lead to significant healthcare and social support costs. The prevalence increases with ageing, and as the lifespan of individuals is increasing and skeletal health is decreasing due to lifestyle factors such as obesity and lack of physical activity, the burden of bone pain on individuals and society is expected to further increase in the coming decades. Bone pain is notoriously difficult to treat with the available analgesics and there is a huge need for mechanism-based treatments. Therefore, it is pertinent to train highly skilled researchers to promote frontline research, innovation and education within bone pain. In BonePainIII we bring together 3 industrial beneficiaries, 4 academic beneficiaries, two industrial partners and three academic partners in a highly interdisciplinary and intersectoral network encompassing bioengineering, neuroscience, pharmacology, drug discovery and clinical medicine. BonePainIII will train a new generation of 10 creative, entrepreneurial and innovative early stages researchers (ESR), who in a doctoral programme will achieve research specific and transferable competences. The transferable skills program consists of workshops and courses covering essentials skills for a successful career in academic or non-academic sectors and includes entrepreneurship, knowledge transfer, open science, coding and artificial intelligence, communication, self-marketing, outreach, intellectual property rights, and environmental practices. A strong participation of the non-academic sector committed to hosting ESRs and to train through secondments and workshops ensures that the ESRs will be exposed to both academia and industry, and a gender balanced supervisor group will counteract gender-related barriers.Two major obstacles hamper drug discovery in bone pain: 1) the lack of understanding of the underlying molecular and cellular mechanisms of bone pain, and 2) a translational gap to the clinic. In BonePainIII, we will address these challenges through four integrated and ambitious, yet achievable research work packages.