PATHOGENESIS AND PREVENTION OF OSTEOPOROSIS

这是基础和临床项目补助金的延续 与骨质疏松症有关的研究。 它包括一个行政核心， 分子组织学和转基因动物核心实验室，以及四个主要的 项目 这些项目是：1）研究性激素对 骨形成和前列腺素的产生，2）研究 糖皮质激素对胶原基因表达的影响，3）开发新的 转基因模型，以评估激素和组成型调节 体内骨基质合成; 4）性激素作用的研究 对细胞因子的产生和破骨细胞的形成和功能的影响。 这些 项目将与其他正在进行的研究工作密切结合， 骨代谢目前正在进行的大学 康涅狄格州健康中心及其附属机构，包括 一般临床研究中的实验室研究和临床研究 中心（GCRC）和骨质疏松症中心。 一个程序的存在 骨质疏松症在产生新的研究中至关重要 参与骨研究的许多教师之间的相互作用， 结缔组织代谢和肌肉骨骼疾病， 机构。 它导致了新的倡议，在应用分子 生物学和遗传学技术对骨质疏松症发病机制的研究进展。 未来 在计划项目赠款的互动应该帮助我们提供新的 知识，并导致更好地了解发病机制和更多 预测、预防和治疗骨质疏松症的有效途径。

This is a continuation of a Program Project Grant on basic and clinical studies related to osteoporosis. It includes an administrative core, molecular histology and transgenic animal core laboratories, and four major projects. The projects are 1) studies on the effects of sex hormones on bone formation and prostaglandin production, 2) studies on the role of glucocorticoids on collagen gene expression, 3) the development of new transgenic models to assess the hormonal and constitutive regulation of bone matrix synthesis in vivo and 4) studies on the effect of sex hormones on cytokine production and osteoclast formation and function. These projects will be closely integrated with other ongoing research efforts in bone metabolism currently being carried out at the University of Connecticut Health Center and its affiliated institutions, including laboratory studies and clinical research in the General Clinical Research Center (GCRC) and the Osteoporosis Center. The existence of a Program Project is osteoporosis has been vital in generating new research interactions among the many faculty involved in studies on bone and connective tissue metabolism and musculoskeletal disease at this institution. It has led to new initiatives in the application of molecular biology and genetic techniques to the pathogenesis of osteoporosis. Future interactions in the Program Project Grant should help us to provide new knowledge and lead to a better understanding of pathogenesis and more effective approaches to prediction, prevention and therapy in osteoporosis.