BIOLOGY OF CHILDHOOD NEPHROTIC SYNDROME

这项儿科肾脏病的所有七名参与研究人员 组织一直以来都有兴趣描述 肾小球损害的致病/病理生理机制 功能和结构在各种肾脏和泌尿系统疾病中的作用。 来自这些研究的新发现与所做的工作相结合 由其他人撰写了几篇全面的评论，讨论 每种类型肾功能衰竭的病理生理学的当代观点，即， 肾前性、肾性、肾后性以及慢性肾功能衰竭。 对我们目前对致病/的知识的批判性评估 病理生理过程使我们相信，要达到下一步 要理解这些流程，需要应用最新的 生物化学和分子生物学技术。它是考虑到这一点的 每个参与者都参与了与 基础科学前沿的专家。幸运的是， 范德比尔特既有天赋又有独特的氛围 鼓励联合行动。为响应“儿科”的号召 肾脏和泌尿外科中心拨款申请，我们决定整合 通过这些项目获得的现有人才、知识和技能 深入开展一个选定领域的合作。我们已经选择了 儿童肾病综合征不仅考虑到这个问题的严重性 儿科临床中的问题，但也因为它与 这些调查人员正在进行的研究。因为这个问题出现了 与成熟发育密切相关的肾小球研究 成熟也是我们目标的重要组成部分。

All seven participating investigators within this Pediatric Nephrology Division have had a long-standing interest in delineating the pathogenic/pathophysiologic mechanisms underlying impaired glomerular function and structure in a variety of nephrologic and urologic diseases. The new findings stemming from these studies were integrated with work done by others in producing several comprehensive reviews discussing the contemporary view of pathophysiology of each type of renal failure, namely, pre-renal, renal, post-renal failures as well as chronic renal failure. Critical assessment of our current knowledge of the pathogenic/ pathophysiologic processes has led us to believe that to attain the next level of understanding these processes require application of the newest biochemical and molecular biological technologies. It is with this in mind that each of the participants has become engaged in collaboration with experts in the forefront of basic sciences. It is fortunate that Vanderbilt has both the talent and unique atmosphere where such associations are encouraged. In response to the call for "Pediatric Nephrology and Urology Center Grant" application, we decided to integrate the existing talent, knowledge and skills acquired through these collaborations to pursue in depth one selected area. We have chosen childhood nephrotic syndrome in view not only of the magnitude of this problem in clinical pediatrics, but also because of its direct relevance to ongoing research by these investigators. Since this problem appears closely linked to maturational development, the study of glomerular maturation has also been integrated as an important part of our goals.