MODIFICATION OF DIET IN RENAL DISEASE STUDY

杜克大学医学中心肾脏科 申请参加第三和第四阶段的 饮食调整在病程中的临床协同研究 进展性肾病（MDRD研究）。 MDRD研究 测试有效性、安全性和 蛋白质和磷酸盐饮食改良的可接受性 肾小球滤过率降低的患者， 各种病因的肾脏疾病。 研究方案有 在计划期间由NIH设计和测试， 可行性阶段。 新寻求的其他中心， 统计学上有效的患者数量，并扩大 地域代表性。 目前的提案可以纳入 来自北卡罗来纳州的皮埃蒙特地区和邻近地区的患者 主要来源为所服务患者人群的国家 由杜克大学和达勒姆退伍军人管理局 医疗中心及其转诊医生。 大战略 以确保入组40-50例合格受试者。 这些战略部分是基于最近的经验， 在临床研究中招募大量患者， 高血压 这项研究将使用杜克大学临床 研究股门诊设施，主要关注 研究营养师在实施 治疗方案

The Division of Nephrology of Duke University Medical Centers applying to participate in phases III and IV of the Cooperative Clinical Study of Dietary Modification on the Course of Progressive Renal Disease (MDRD study). The MDRD Study has the three-fold objectives of testing the effectiveness, safety, and acceptability of dietary modifications of protein and phosphate in patients with reductions in glomerular filtration rate from renal diseases of various etiologies. The research protocols have been deigned and tested by the NIH during the planning and feasibility phases. Additional centers are new sought to assure a statistically valid number of patients and to broaden the geographic representation. The present proposal could enroll patients from the piedmont area of North Carolina and contiguous state with primary sources being the patient populations served by the Duke University and the Durham Veterans' administration medical centers and their referring physicians. Major strategies are outlined to assure enrollment of 40-50 eligible subjects. These strategies are based in part on recent experience in enrolling large numbers of patients in clinical studies involving hypertension. The study would use the Duke University Clinical research Unit outpatient facilities with major attention to the critical role of the study dieticians in implementing the treatment program.