MORPHOMETRY OF THE GLOMERULUS IN PIMAS AND OTHER MINORITY POPULATIONS

面积的加权平均值和 用计算机辅助求积仪计算肾小球 糖尿病和非糖尿病皮马印第安人的尸检肾脏标本。 这些形态学变量也与 组织学肾小球病变，按四级量表分级。 肾小球 两组的大小没有差异， 在组织学病变的类别中分布明显。 一 在Causcasian NIDDM人群中发现了类似的模式。 这些 数据与胰岛素依赖型糖尿病相反， 肾小球大小，其次是肾小球大小的晚期减少， 阶段性肾病并发症。 糖尿病皮马印第安人的肾小球 在弥漫性硬化阶段， 与其他类型的肾病中常见的情况相比， 尤其是与血管病变相关的那些。 之间的比较 白种人和黑人尸检标本中肾小球的大小 也对没有肾病的个体进行了研究。

The weighted mean of the area and a size-class distribution of the glomeruli were calculated with a computer-assisted planimeter in a series of autopsy kidney specimens of diabetic and non-diabetic Pima Indians. These morphometric variables were also related to the severity of histologic glomerular lesions, graded on a four class scale. Glomerular size did not differ in the two groups, nor were differences in the size distribution discernible among the classes of histologic lesions. A similar pattern was found in a Causcasian population with NIDDM. These data are in contrast to IDDM where there is an early increase in glomerular size, followed by a late decrease in glomerular size as end- stage renal disease supervenes. The glomeruli of diabetic Pima Indians did not decrease in size at the stage of diffuse sclerosis, a finding that contrasts with what is commonly seen in other types of kidney disease, especially those associated with vascular lesions. Comparisons between the size of the glomeruli in autopsy specimens from caucasian and black individuals devoid of renal disease was also undertaken.