NATURAL HISTORY OF ARTHRITIS AND RHEUMATISM ON THE GILA RIVER INDIAN COMMUNITY

骨关节病、类风湿性关节炎的发生发展 和强直性脊柱炎正在通过临床， 预期在以下地点进行放射和血清学检查 吉拉河印第安人社区(PIMA)成年人之间的两年间隔 印第安人)在亚利桑那州，与流行病学研究一起 糖尿病患者在同一个社区。这次调查的目的是 确定这些疾病在人群中的决定因素，并 确定倾向于或改变自然历史的因素 疾病的发展。宿主因素，如年龄、性别和各种 包括人类白细胞抗原和粒细胞集落刺激因子在内的基因标记物及其各种潜力 环境决定因素，如肥胖和暴露于 感染性因素，正在进行前瞻性调查，以确定他们 与这些疾病的发展之间的关系。纵向数据有 现在已经收集了25年，代表着一个独特的数据集 关节炎的流行病学研究。

The development and progression of osteoarthrosis, rheumatoid arthritis and ankylosing spondylitis are being determined by means of clinical, radiographic and serological examinations carried out prospectively at two-yearly intervals among adults of the Gila River Indian Community (Pima Indians) in Arizona, in conjunction with epidemiological studies of diabetes in the same community. The purpose of this investigation is to ascertain the determinants of these diseases in the population, and to identify factors which predispose to or alter the natural history of progression of the disease. Host factors such as age, sex, and various gene markers including HLA and Gm, together with various potential environmental determinants, such as obesity and evidence of exposure to infectious agents, are being investigated prospectively to determine their relationship to the development of these diseases. Longitudinal data have now been collected for 25 years and represent a unique data set for epidemiological studies of arthritis.