SCOR IN CARDIOPULMONARY DISORDERS OF SLEEP

这项SCOR拨款解决了与睡眠障碍相关的症状 呼吸，认为发病机制和最终控制需要 对代谢、神经生理学和生理学有详细的了解 呼吸暂停、睡眠障碍和缺氧的特征。我们将解决如何 随着时间的推移，宿主对睡眠呼吸暂停事件的反应会导致 心血管、呼吸、神经心理和行为问题 归因于睡眠呼吸暂停。为了实现这些目标，我们提出了六点建议 相互关联的项目，从多个角度和更多方面进行审查 时间，睡眠呼吸暂停，缺氧，代谢和生长调节因素， 和共病(高血压、肥胖症、糖耐量低减、酒精、 和其他疾病)作用和相互作用以产生症状性疾病和/或 影响治疗结果。项目1考察了低氧在脑内的作用 以胰岛素抵抗的发生率和机制为共同点 睡眠呼吸暂停与心血管疾病发病率之间的关系。 项目2将解决中枢5-羟色胺的分布问题 神经递质的异质性与呼吸控制和 睡眠呼吸暂停患者治疗前后的呼吸暂停。项目 3重点阐述了咽肌和缺氧的潜在作用 钾离子通道在决定肌肉紧张和疲劳中的作用。 项目4针对的是大脑的机制和后果 血管对低氧的适应。项目5系统地描述了 神经心理缺陷在患者中的分布与 治疗前后共病情况。项目6操作和定义 酒精、缺氧和病程等因素会改变 睡眠患者的睡眠、警觉性和/或认知表现 呼吸暂停。两个内核提供管理和生物识别支持 项目。这种跨学科的方法将提供新的信息。 睡眠呼吸暂停对细胞和器官系统的影响并提供 了解治疗的必要性和途径所需的信息 防止睡眠障碍的呼吸。

This SCOR grant addresses the syndromes related to sleep-disordered breathing with the view that pathogenesis and ultimate control requires a detailed understanding of metabolic, neurophysiologic, and physiologic featrues of apnea-disturbed sleep and hypoxia. We will address how the host response to sleep apneic events results over time in the cardiovascular, respiratory, neuropsychologic, and behavioral problems attributed to sleep apnea. To achieve these aims, we propose six interrelated projects that examine, from multiple perspectives and over time, how sleep apnea, hypoxia, metabolic and growth regulatory factors, and co-morbidity (hypertension, obesity, glucose intolerance, alcohol, and other disease) act and interact to produce symptomatic disease and/or influence treatment outcome. Project 1 examines the role of hypoxia in the incidence of and mechanisms for insulin resistance as common ground for associations between sleep apnea and cardiovascular morbidity. Project 2 will address the distribution of central serotonin neurotransmitter heterogeneity in relation to respiratory control and apneas before and after treatment in patients with sleep apnea. Project 3 focuses on pharyngeal muscles and hypoxia and the potential role of potassium ion channels in determining muscle tension and fatigue. Project 4 is directed at the mechanisms and consequences of brain vascular adaptations to hypoxia. Project 5 systematically describes the distribution of neuropsychologic deficits in patients in relation to comorbidity before and after therapy. Project 6 manipulates and defines factors such as alcohol, hypoxia, and length of illness that modify sleep, alertness, and/or cognitive performance in patients with sleep apnea. Two cores provide administrative and biometrics support for all projects. This interdisciplinary approach will provide new information on the impact of sleep apnea on cellular and organ systems and provide information necessary to understand the need for therapy and avenues for prevention of sleep-disordered breathing.