Cutting through complexity: the promise of biomarkers to discover, diagnose, and treat antibody-associated demyelination

髓鞘（大脑中神经细胞周围的鞘）受损的患者患有“脱髓鞘紊乱”，可能导致严重的残疾，包括失明和瘫痪。在一些病人身上，他们的免疫系统错误地瞄准了大脑中的某些蛋白质。该研究项目将确定目前未确诊患者的新靶点，增加我们对潜在疾病过程的理解，并评估这些患者的最佳治疗策略，以改善其预后。

Patients with damage to myelin, the sheath around nerve cells in the brain, have “demyelinating disorders” which can result in severe disability including blindness and paralysis. In some patients, their immune system mistakenly targets certain proteins in the brain. This research project will identify new targets in currently undiagnosed patients, increase our understanding of underlying disease processes, and evaluate optimal treatment strategies in these patients to improve their outcomes.