GENERAL CLINICAL RESEARCH CENTER

目前的建议要求继续支持多学科的 一般临床研究中心，涉及成人和 孩子 临床研究中心的目标是 密歇根大学将在人类身上进行有价值的研究， 这有助于我们更好地理解人类生物学， 疾病，疾病过程的阐明，或新的方法， 人类疾病的诊断和管理。 此外该 临床研究中心旨在发挥以下作用：（a）机构 资源作为临床研究培训的重点，以及（B）作为 一个国家和州的资源，以补充病人护理的发现， 新知识，以协助和改善诊断和管理 患者 过去六年，我们为达致这些目标而进行的工作包括 一系列重大进展和成就， 为改善医疗保健做出贡献。 另外很多 受训者已接触到临床研究中心的环境。 在今后五年中，我们建议继续努力， 目标是超过160个独立的临床研究方案， 研究范围从正常人的生理和生化研究， 人体机能、分子病理学和病理生理学研究 人类疾病状态，临床试验，以改变人类疾病状态 既有既定的治疗方法，也有实验性的治疗方法， 药代动力学研究，以了解代谢和分布 具体药物。 为了支持这项活动，需要住院服务， 门诊服务，计算设施，生物统计咨询 服务，核心实验室与一个新的人类细胞遗传学设施， 行政服务，以及一系列复杂的物理设施， 设备. 参与这项研究的调查人员包括 来自内科，外科， 儿科学，人类遗传学，药理学，精神病学，生理学， 生物化学、神经病学、皮肤病学、放射学、物理学 医学和康复，放射治疗，耳鼻喉科， 公共卫生学院、护理学院和药学院。 提出了一项涉及临床助理的实质性培训计划 医生，研究员，内科住院医生，医学生， 护理专业学生、营养学专业学生和营养师。 预计 这项研究将促进人们对 在许多领域中的正常人体功能和疾病状态。 继续 临床研究中心的支持将提供一个稳定的重点， 密歇根大学的临床研究。

The current proposal requests continuing support for a multidisciplinary General Clinical Research Center involving research on both adults and children. The objective of the Clinical Research Center at the University of Michigan is to perform meritorious research in humans, which leads to an improved understanding of human biology, the prevention of disease, the elucidation of disease processes, or novel approaches to the diagnosis and management of diseases in humans. In addition, the Clinical Research Center aims to function as: (a) an institutional resource as a focal point for training in clinical research and (b) as a national and state resource to complement patient care by the discovery of new knowledge to assist and improve the diagnosis and management of patients. Our work to achieve these goals during the past six years includes a series of important advances and achievements which are already contributing to the improvement of health care. In addition, many trainees have been exposed to the Clinical Research Center environment. During the next five years we propose to continue to work towards our goal with over 160 separate clinical research protocols which involve studies ranging from physiological and biochemical studies of normal human function, studies of the molecular pathology and pathophysiology of human disease states, clinical trials to modify human disease states with both established and experimental forms of therapy, and pharmacokinetic studies to understand the metabolism and distribution of specific drugs. To support this activity requires an inpatient service, outpatient service, computing facility, Biostatistical Consulting Service, Core Laboratory with a new Human Cell Genetics Facility, Administrative Service, and a complex series of physical facilities and equipment. The investigators involved in the research include individuals from the Departments of Internal Medicine, Surgery, Pediatrics, Human Genetics, Pharmacology, Psychiatry, Physiology, Biological Chemistry, Neurology, Dermatology, Radiology, Physical Medicine and Rehabilitation, Radiation Therapy, Otorhinolaryngology, School of Public Health, School of Nursing, and College of Pharmacy. A substantial training program is proposed involving Clinical Associate Physicians, fellows, Internal Medicine residents, medical students, nursing students, dietetic students and dietitians. It is anticipated that the research proposed will bring advances in the understanding of normal human function and disease states in many fields. Continuing support of the Clinical Research Center will provide a stable focus for clinical research at the University of Michigan.