TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF ZIDOVUDINE (AZT) IN CHILDREN

这是一项高剂量与低剂量齐多夫定的III期试验 对有症状的艾滋病毒感染的儿童。治疗将继续进行 直到最后一位登记的患者已经接受了104周的治疗，并直接 将对两者的耐受性和副作用进行评估 治疗方案，艾滋病毒感染的进展，以及 神经发育疾病的变化。我们将比较以下几个方面： 临床、免疫学和病毒学参数分组。

This is a Phase III trial of high versus low dose zidovudine administered to children with symptomatic HIV infection. Treatment will continue until the last patient enrolled has received 104 weeks, and direct assessments will be made for tolerance and side effects of the two regimens, for the progression of HIV infection, and for the degree of change in neurodevelopmental disease. Comparisons will be made between groups for clinical, immunological, and virological parameters.