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CONTROL OF TOLERANCE TO CHRONIC APOMORPHINE STIMULATION IN PARKINSON'S DISEASE

CONTROL OF TOLERANCE TO CHRONIC APOMORPHINE STIMULATION IN PARKINSON'S DISEASE
控制帕金森病慢性阿扑吗啡刺激的耐受性
批准号：
3786511
负责人：
STEPHEN T GANCHER
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3786511
关键词：
Parkinson's disease antiparkinson drugs apomorphine drug adverse effect drug screening /evaluation drug tolerance human subject human therapy evaluation neuromuscular disorder chemotherapy pharmacokinetics

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中文摘要
翻译
这些研究的目的是设计更好的治疗帕金森症的方法 并探讨阿扑吗啡在治疗 剧烈波动。 我们相信在帕金森病患者中 波动，对多巴胺能刺激的敏感性降低 在治疗的几个小时内发生，但是这种损失 几小时后灵敏度反转。
英文摘要
The aim of these studies is to design better therapies for parkinsonism and to investigate the practicality of apomorphine in the treatment of severe fluctuations. We believe that in the parkinsonian patient with fluctuations, a decrease in the sensitivity to dopaminergic stimulation occurs within several hours of treatment, but that this loss of sensitivity is reversed after a several hour period.
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会议论文
SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
SUBLINGUAL APOMORPHINE IN PARKINSON'S DISEASE--TOLERABILITY AND EFFICACY
ALTERATIONS IN DOPAMINERGIC RESPONSE IN PARKINSONISM