MULTIPURPOSE ARTHRITIS & MUSCULOSKELETAL DISEASES CENTER

多功能关节炎和肌肉骨骼疾病中心 位于查佩尔山的北卡罗来纳州大学 医学作为瑟斯顿关节炎研究中心，由一个 生物医学研究组成部分，教育，流行病学和健康 服务研究（E/E/HSR）组件，生物分子核心，数值 科学核心，和一个行政单位。 正在进行的调查 生物医学研究部分包括许多相关的问题， 自身免疫、关节炎和肌肉骨骼疾病：遗传学， 正常和异常的识别元件的调节和功能 免疫反应;肽/MHC结构功能关系;诱导 以及细胞因子和炎症反应基因的调节; T细胞受体和B细胞IG基因库及其在 自身免疫;干细胞发育;异常T细胞活化和 SLE信号转导;自身抗体形成的分子遗传学; 自身抗体对疾病发病机制的贡献; 免疫抑制;自身免疫中的激发剂（细菌细胞壁， 热休克蛋白，氯化汞）;实验性炎症 关节炎及其治疗;骨关节炎生物化学;实验 骨科研究;肌肉代谢;和临床调查。 生物分子核心将提供数据库支持、DNA测序、流程 细胞计数和小鼠集落支持正在进行的实验室研究。 提出了三个开发和可行性项目：1）D&F项目 #1涉及磷脂自身抗体的基础研究，即 与血栓形成，复发性流产， 和血小板减少症; D&F项目#2建议克隆和表征 与肌肉代谢缺陷相关的基因; D&F项目#3 探讨了IkappaB的作用，IkappaB是一个重要的调节因素， 诱导SLE T细胞中的炎性基因。 领域专项 E/E/HSR组件的重点，该组件服务于北卡罗来纳州， 周边国家，包括：社会和行为研究， 骨关节炎流行病学、工作残疾、健康促进/疾病 预防，卫生服务研究，老年人关节炎，低 背痛。 提出了四个E/E/HSR项目：项目#1需要一个 新行为科学概念的系统检查和综合 作为一种发展有效、高效的干预策略的手段， 病人教育;项目#2检查流行病学， 骨关节炎及其对少数民族劳动参与影响 和经济上处于不利地位的公民;项目#3和#4， 将记录与关节炎相关的自我护理行为， 老年人，并检查接近更年期的妇女 认识到他们患骨质疏松症的风险增加，并采取适当的措施， 预防行为。 向E/E/HSR组件提供的支持 数字科学核心包括：数据输入，数据管理， 规划和咨询有关的研究设计，方法， 和数据分析。

The Multipurpose Arthritis & Musculoskeletal Diseases Center at the University of North Carolina at Chapel Hill, chartered by the School of Medicine as the Thurston Arthritis Research Center, consists of a Biomedical Research Component, an Education, Epidemiology, & Health Services Research (E/E/HSR) Component, a Biomolecular Core, a Numerical Sciences Core, and an Administrative Unit. Ongoing Investigation in the Biomedical Research Component encompasses many of the issues relevant to autoimmunity, arthritis, and musculoskeletal disease: genetics, regulation, and function of recognition elements in normal and abnormal immune responses; peptide/MHC structure function relationships; induction and regulation of cytokine and inflammatory response genes; the repertoire of T cell receptor and B cell Ig genes and their role in autoimmunity; stem cell development; abnormal T cell activation and signal transduction in SLE; molecular genetics of autoantibody formation; contribution of autoantibodies to disease pathogenesis; immunosuppression; inciting agents in autoimmunity (bacterial cell walls, heat-shock proteins, mercury chloride); inflammation in experimental arthritis, and its therapy; biochemistry of osteoarthritis; experimental orthopaedics research; muscle metabolism; and clinical investigation. The Biomolecular Core will provide database support, DNA sequencing, flow cytometry, and mouse colony support for ongoing laboratory research. Three Developmental & Feasibility projects are proposed: 1) D&F project #1 involves basic studies on autoantibodies to phospholipids, which are associated with an increased risk of thrombosis, recurrent fetal loss, and thrombocytopenia; D&F project #2 proposes to clone and characterize a gene associated with a defect in muscle metabolism; D&F project #3 explores the role of IkappaB, an important regulatory element for induction of inflammatory genes, in SLE T cells. Areas of special emphasis in the E/E/HSR Component, which serves North Carolina and surrounding states, include: social and behavioral research, epidemiology of osteoarthritis, work disability, health promotion/disease prevention, health services research, arthritis in the elderly, and low back pain. Four E/E/HSR projects are proposed: project #1 entails a systematic examination and synthesis of novel behavioral science concepts as a means of developing an effective, efficient intervention strategy for patient education; project #2 examines the epidemiology of osteoarthritis and its influence on work force participation in minority and economically disadvantaged citizens; projects #3 and #4, respectively, will document the arthritis-related self-care behaviors of the elderly and examine the extent to which women approaching menopause recognize their increasing risk of osteoporosis and practice appropriate preventive behaviors. Support provided to the E/E/HSR Component by the Numerical Sciences Core includes: data entry, data management, programming, and consultation concerning research design, methodology, and data analysis.