MODIFICATION OF DIET IN RENAL DISEASE STUDY

此申请是为了参加合作临床 饮食调整对进展性肾功能衰竭病程的影响 疾病（MDRD研究）。 MDRD是一个多中心协作 临床试验旨在确定是否有膳食蛋白质 限制可能会影响慢性肾脏疾病的进展速度， 无论原发性基础疾病的性质如何 过程 乔治华盛顿大学医学院和 乔治城大学医学院都位于 华盛顿、哥伦比亚特区已决定参加 学习作为一个中心。 研究计划的目的是 证明：1）这些大学的肾脏部门 有兴趣，经验，设施和病人资源 有必要参加这项研究。 利息是由于 大都会华盛顿地区的独特性 就流行率而言（每106人中有1，437.6人，而每106人中有405.2人）， 106例）和发病率（375.3/106 与之相比，该国其他地区每106人中有143.1人 肾脏疾病 作为一个财团GWU参与研究- GU将集中资源，避免机构竞争。 私人保险公司和私人保险公司的经验。将允许合作 并顺利完成研究。 两者的设施 肾脏部门对本研究来说绰绰有余。 办公空间 将专门用于这项研究。 病人资源。 两个部门均面向大型患者的临床 人口和临床研究设施。 1)计划 招聘活动包括广泛利用地方政府 办公室，研究将由公共事务专员支持。 至少有17个外围门诊设施， 社区的宗教领袖。 广电和 将开始报纸宣传活动。 （三）潜在来源 患者：在GWU：包括，当地HMO，内部部门 医学，哥伦比亚特区门诊健康诊所， 私人医生 在GU：包括门诊临床的 肾脏科和私人医生。 四）预计患者 池：我们估计，在GWU，我们已经有20名患者， 我们自己的A组档案 在B组中，我们有10名患者， 文件. 在GU，A组有10名患者， B组。 因此，总共需要招聘5- 10人。 患者在21个月的招募期内。

This application is to participate in the Cooperative Clinical Study of Dietary Modification on the Course of Progressive Renal Disease (MDRD Study). The MDRD is a multicenter collaborative clinical trial designed to ascertain whether or no dietary protein restriction may influence the rate of progression of chronic renal disease irrespective of the nature of the primary underlying process. George Washington University Medical School and Georgetown University School of Medicine both located in Washington, District of Columbia have decided to participate in the study as one center. The Objectives of the Research Plan are to demonstrate: 1) That the Renal Divisions of these Universities have the interest, experience, facilities and patient resources necessary to participate in this study. The interest is due to the unique characteristics of the Greater Metropolitan Washington Area in terms of the prevalence (1,437.6 per 106 compared to 405.2 per 106 in the est of the country) and incidence (375.3 per 106 compared to 143.1 per 106 in the rest of the country) of chronic renal disease. By participating in the study as a consortium GWU- GU will pool their resources and avoid institutional competition. The experience of the P.I and Co P.I. will allow for cooperation and successful completion of the study. The facilities of both Renal Divisions are more than adequate for the study. Office space will be exclusively dedicated for the study. Patient resources. Both Divisions are clinically oriented with large patient population and facilities for clinical research. 1) The Planned Recruitment Campaign includes extensive use of Local Government offices, the study will be supported by the Commissioner of Public Health with at least 17 peripheral outpatient facilities, and religious leaders of the community. Radio, Television and Newspaper campaigns will be started. III) Potential Sources of Patients: At GWU: Include, the local HMO, the Division of Internal Medicine, Outpatient Health Clinics of the District of Columbia, private physicians. At GU: Include the outpatient clinical of the Renal Division and private physicians. IV) Estimated Patient pools: We estimate that at GWU we already have 20 patients from our own files for Group A. In Group B we have 10 patients from our files. At GU we have 10 patients for Group A and 20 patients in Group B. Therefore it will require a total recruitment of 5- 10 patients in the 21 months recruitment period.