HHV-6 DNA INDUCED TUMORS AND TUMOR INFILTRAION LYMPHOCYTES (TIL)

我们报道了HHV-6DNA转化的NIH 3T3细胞在 裸鼠及其肿瘤细胞对免疫活性NIH的致瘤作用 瑞士老鼠。HHV-6基因组可产生肿瘤特异性TIL DNA诱导的肿瘤。我们最近报道了一个HHV-6亚基因组克隆 PZVH14诱导的肿瘤细胞(14-2T)肺转移 静脉注射免疫能力强的小鼠。磁贴也可以是 然而，从这些14-2T来源的肿瘤中产生的TIL缺乏 肿瘤特异性溶血特性。这项工程涉及发电 由于人员不足，TILs将暂时停产 和适当的资源。然而，识别和映射 转化基因将在其他项目中进行。

We reported that HHV-6 DNA transformed NIH 3T3 cells produced tumors in nude mice and these tumor cells were tumorigenic in immunocompetent NIH Swiss mice. Tumor specific TIL could be generated from HHV-6 genomic DNA induced tumors. We recently reported that a HHV-6 subgenomic clone pZVH14-induced tumor cells (14-2T) metasta- sized to the lungs upon intravenous injection into immunocompetent mice. TILs could also be generated from these 14-2T derived tumors, however, these TILs lacked tumor specific lytic property. This project involving generation of TILs will be discontinued temporarily because of the lack of personnel and appropriate resources. However, identification and mapping of the transforming gene will be pursued in other projects.