REACTIONS FOLLOWING IMMUNIZATION WITH JAPANESE ENCEPHALITIS VIRUS VACCINE

乙型脑炎病毒是急性脑炎的病原体。 中枢神经系统炎症性疾病 东亚。一种福尔马林灭活的小鼠脑衍生日本人 脑炎病毒疫苗已经研制成功。一份严重的报告 与日本疫苗接种相关的麻疹反应 脑炎病毒疫苗于1991年发表在《柳叶刀》杂志上。这个 严重不良反应发生率为0.04%。该描述 的不良反应与以下情况下的过敏反应相似 接种了加强剂量的狂犬病疫苗。美国疾病控制中心 控制部门被邀请参与对反应堆的调查。 一项病例对照研究发现，发生这些反应的人在 接种乙脑疫苗的人更有可能有过往的荨麻疹病史 (在膜翅目毒化、毒品、身体或其他挑衅之后 或特发性原因)。对16个反应堆进行了皮肤测试 疫苗接种后至少5周引起过敏反应 反应。没有一个反应堆的皮肤试验呈阳性。急性和 抽取恢复期血清进行IgE水平和反应性检测 带着疫苗。这些测试仍在进行中。该机制和 这些反应的原因尚不清楚。疫苗的标签将会 包括足够的警告，以告知医生和接受者 关于过敏反应的疫苗。

Japanese encephalitis virus is the causative agent of an acute inflammatory illness of the central nervous system found throughout eastern Asia. A formalin inactivated, mouse-brain derived Japanese encephalitis virus vaccine has been developed. A report of severe urticarial reactions associated with immunization with Japanese encephalitis virus vaccine was published in 1991 in The Lancet. The rate of severe side-effects was reported to be 0.04%. The description of the adverse reactions was similar to allergic reactions seen when booster doses of rabies vaccine were given. The Centers for Disease Control were invited to participate in an investigation of the reactors. A case-control study found that persons developing these reactions after JE vaccination were more likely to have had a past history of urticaria (after hymenoptera envenomation, drugs, physical or other provocations or of idiopathic cause). Sixteen reactors were skin tested with the vaccine causing the allergic reaction at least 5 weeks after the reaction. None of the reactors showed skin test positivity. Acute and convalescent sera were drawn for testing for IgE levels and reactivity with the vaccine. These tests are still in progress. The mechanism and cause of these reactions is still unknown. The vaccine labeling will include adequate warnings to inform physicians and recipients of the vaccine about the allergic reactions.