MODIFICATION OF DIET IN RENAL DISEASE STUDY

本次申请是为了参加合作临床 进展性肾脏病程中饮食调理作用的研究 疾病(MDRD研究)。MDRD是一个多中心协作式 临床试验旨在确定是否有饮食蛋白质 限制措施可能会影响慢性肾脏的进展速度 无论主要潜在疾病的性质如何 进程。乔治华盛顿大学医学院和 乔治城大学医学院都位于 华盛顿哥伦比亚特区已决定参加 把学习作为一个中心。研究计划的目标是 证明：1)这些大学的肾科 有兴趣，有经验，有设施，有病人资源 有必要参与这项研究。利息是由于 大都会华盛顿地区的独特特征 就流行率而言(每106人中有1,437.6人，而每106人中有405.2人 106%)和发病率(375.3/106% 相比之下，该国其他地区每106人中有143.1人)慢性 肾脏疾病。作为GWU财团参与这项研究- GU将集中他们的资源，避免机构竞争。 P.I和CoP.I.的经验将允许合作 并圆满完成了研究。两家公司的设施 肾脏分区对于这项研究来说是绰绰有余的。办公空间 将专门用于这项研究。病人资源。 这两个科室都是面向临床的大病人 用于临床研究的人口和设施。1)计划中的 招聘活动包括广泛使用地方政府 办公室，这项研究将得到公共事务专员的支持 拥有至少17个外围门诊设施的健康中心，以及 社区的宗教领袖。广播、电视和 将启动报纸宣传活动。三)潜在的来源 患者：在GWU：包括当地HMO，内科 医学，哥伦比亚特区门诊部， 私人医生。在顾：包括医院的门诊。 肾科和私人医生。四)预估病人 Pools：我们估计在GWU我们已经有20名来自 我们自己的A组档案。在B组，我们有10名患者来自我们的 档案。在GU，我们有10名A组患者和20名 B组因此，将需要总共征聘5-10人 患者在21个月内招募。

This application is to participate in the Cooperative Clinical Study of Dietary Modification on the Course of Progressive Renal Disease (MDRD Study). The MDRD is a multicenter collaborative clinical trial designed to ascertain whether or no dietary protein restriction may influence the rate of progression of chronic renal disease irrespective of the nature of the primary underlying process. George Washington University Medical School and Georgetown University School of Medicine both located in Washington, District of Columbia have decided to participate in the study as one center. The Objectives of the Research Plan are to demonstrate: 1) That the Renal Divisions of these Universities have the interest, experience, facilities and patient resources necessary to participate in this study. The interest is due to the unique characteristics of the Greater Metropolitan Washington Area in terms of the prevalence (1,437.6 per 106 compared to 405.2 per 106 in the est of the country) and incidence (375.3 per 106 compared to 143.1 per 106 in the rest of the country) of chronic renal disease. By participating in the study as a consortium GWU- GU will pool their resources and avoid institutional competition. The experience of the P.I and Co P.I. will allow for cooperation and successful completion of the study. The facilities of both Renal Divisions are more than adequate for the study. Office space will be exclusively dedicated for the study. Patient resources. Both Divisions are clinically oriented with large patient population and facilities for clinical research. 1) The Planned Recruitment Campaign includes extensive use of Local Government offices, the study will be supported by the Commissioner of Public Health with at least 17 peripheral outpatient facilities, and religious leaders of the community. Radio, Television and Newspaper campaigns will be started. III) Potential Sources of Patients: At GWU: Include, the local HMO, the Division of Internal Medicine, Outpatient Health Clinics of the District of Columbia, private physicians. At GU: Include the outpatient clinical of the Renal Division and private physicians. IV) Estimated Patient pools: We estimate that at GWU we already have 20 patients from our own files for Group A. In Group B we have 10 patients from our files. At GU we have 10 patients for Group A and 20 patients in Group B. Therefore it will require a total recruitment of 5- 10 patients in the 21 months recruitment period.