STUDY OF SURGERY AND PHOTODYNAMIC THERAPY FOR INTRAPERITONEAL MALIGNANCIES

肿瘤弥漫性种植于腹膜腔的患者， 常规治疗预后差。 卵巢癌是一种 其表现为弥漫性累及腹膜的晚期疾病 在23，000名患有卵巢癌的女性中， 美国每年的癌症 无病生存率 这些患者在5年时接受常规治疗的比例低于10%， 包括最初的减瘤手术， 化疗 我们已经成功地将一个卵巢肿瘤 在使用腹膜内光动力疗法的小鼠模型中， 即一种光敏剂，其定位于肿瘤中并可被 光来摧毁癌细胞。 我们一直有兴趣 将这一策略应用于卵巢癌患者的管理， 因此启动了第一阶段试验。

The patients with tumors diffusely seeding the peritoneal cavity have a poor prognosis with conventional treatment. Ovarian cancer is one tumor which presents with advanced disease diffusely involving the peritoneal surface in approximately 70% of the 23,000 women who develop ovarian cancer annually in the United States. The disease free survival in these patients at 5 years is less than 10% with conventional management, which involves initial debulking surgery followed by multi-agent chemotherapy. We have been able to sterilize an ovarian tumor similar to this in a mouse model using intraperitoneal photodynamic therapy, i.e. a photosensitizer which localizes in tumor and can be activated by light to destroy cancer cells. We have been interested in incorporating this strategy into the management of patients with ovarian cancer and have thus initiated this Phase I trial.