SPECIALIZED MATERIALS SCIENCE RESEARCH CENTER

该中心提案的主要目标是使用高 要开发的技术概念、仪器和计算机支持 诊断、治疗和分析用材料和分析系统 恢复性应用程序。要探索的概念领域之一是 从粘结剂中控制元素或化合物的释放， 界面膜、表面涂层、空洞准备衬里和根部 根管封闭器用作：1)以下龋齿活动的标志 修复，2)氟化物的时间释放来源，3)钙化 使龋齿组织重新矿化的解决方案、缓冲液和抗菌剂 改变龋齿环境中细菌活性的试剂，以及5) 用于促进闭合和愈合的生物活性界面材料 骨缺损和露出的牙髓组织。最新的突破性进展 聚合物微球技术、微胶囊技术和 生物活性陶瓷的溶胶-凝胶法将成为发展方向 含有控释剂的创新牙科材料。这些 材料应该通过最小化来延长修复体的预期寿命 他们因龋病诊断的不确定性而过早更换 位于牙齿修复界面的位置，通过减少 与现有的龋病复发或龋病进展相关的风险 最大限度地减少对牙髓治疗的需求。另一个 创新的方法将需要立体摄影测量的应用 自动定量分析系统的技术发展方向 生物材料和假体材料上发生的地形变化 表面。从双摄像机系统或 扫描电子显微镜将被光学数字化并存储为 计算机中来自表面地形图的图像文件。自动化 立体摄影测量系统可用于开发CAD-CAM加工 假体和评估磨损或化学降解率的天然 牙齿和修复材料。另一个有待探索的新概念 参与开发一种可浇注的微晶玻璃，内部 通过着色剂元素的交互作用控制着色 或氧化物和热加工。目前可用的可浇铸陶瓷 只能通过涂上一层着色瓷器来着色 在某些情况下，还可以使用有色水泥。远程研究 该中心计划的目标是：1)建立最佳配方 以及开发聚合物微球和聚合物微球的加工技术 用于广谱诊断和治疗的微胶囊给药系统 治疗剂，2)开发修复树脂，提供 控制剂量的氟化物或其他治疗剂 在预计的生命周期内显著的结构退化 修复或应用，3)确定生物活性的有效性 采用溶胶-凝胶技术加工的玻璃，与玻璃形成直接界面 组织和促进牙髓和根尖周区的伤口愈合，4) 自动立体摄影测绘系统的研制 牙齿结构和修复体的地形变化；5) Li2O-CaO-Al_2O_3-SiO_2系陶瓷的研制与性能评价 具有内部色彩控制的微晶玻璃。

The principal objective of this Center proposal is to employ high technology concepts, instrumentation, and computer support to develop materials and analytical systems for diagnostic, therapeutic, and restorative applications. One of the conceptual areas to be explored is the controlled release of elements or compounds from bonding agents, interfacial films, surface coatings, cavity preparation liners, and root canal sealers to serve as: 1) markers of caries activity below restorations, 2) time-release sources of fluoride, 3) calcifying solutions to remineralize carious tissue, 4) buffers and antibacterial agents to alter bacterial activity in carious environments, and 5) bioactive interfacial material used to enhance closure and healing of osseous defects and exposed pulp tissue. Recent breakthroughs in the technology of polymer microspheres, microencapsulation techniques, and sol-gel processing of bioactive ceramics will be used to develop innovative dental materials containing controlled-release agents. These materials should extend the life expectancy of restorations by minimizing their premature replacement due to the uncertainty in caries diagnosis in sites which lie along the tooth-restoration interface, by reducing the risk for recurrent caries or caries progression associated with existing restorations, and by minimizing the need for endodontic therapy. Another innovative approach will entail the application of stereophotogrammetric technology to develop in automated analytical system for quantifying topographical changes that occur on biological and prosthetic material surfaces. Stereopairs of images derived from a two-camera system or scanning electron microscope will be optically digitized and stored as image files in a computer from topographic maps of surfaces. Automated stereophotogrammetric systems can be used to develop CAD-CAM processed prostheses and to evaluate wear or chemical degradation rates of natural teeth and restorative materials. Another novel concept to be explored involves the development of a castable glass-ceramic with internal coloration controlled through the interactive effect of colorant elements or oxides and thermal processing. Currently available castable ceramics can only be shaded by applying an external layer of shading porcelain and, in some cases, by using pigmented cements. The long-range research goals of this Center program are: 1) to establish optimum formulations and processing techniques for development of polymer microsphere and microcapsule delivery systems for a broad spectrum of diagnostic and therapeutic agents, 2) to develop restorative resins which deliver a controlled dose of fluoride or other therapeutic agents without appreciable structural degradation over the projected lifetime of the restoration or appliance, 3) to establish the efficacy of bioactive glasses processed by sol-gel technology which form direct interfaces with tissue and promote wound healing in pulpal and periapical areas, 4) to develop an automated stereophotogrammetric system for mapping topographical changes on tooth structure and restorations, and 5) to develop and assess the performance of a family of Li2O-CaO-Al2O3-SiO2 glass-ceramics with internal coloration control.