PATHOPHYSIOLOGY OF PRESBYACUSIS

建议进行实验，以研究一些 外周听觉发生的生理变化 系统由于在安静环境中老化和在 低水平噪音的环境。我们的主要目标是确定 耳蜗随年龄增长而退化的某些机制 以及长期的噪音暴露。初步结果表明， 沿耳蜗管的离子泵组织功能障碍 可能导致某些类型的听力损失 年龄。还建议进行研究，以检验年龄的一些影响。 以及耳蜗核中二级神经元的噪声。 对耳蜗核的研究目的是为了开始 检查中枢神经系统如何对长期的 低水平的噪音暴露。建议的工作有直接的 与人类研究有关的逐渐丧失的 听力通常见于老年人，这一过程被称为 老年性耳聋。受控制动物的系统研究 各种条件将提供检验各种假说的机会 年龄和环境如何相互作用来改变外设 听觉系统。

Experiments are proposed to investigate some of the physiological changes that take place in the peripheral auditory system as the result of aging in a quiet environment and aging in an environment of low-level noise. Our major goal is to identify some of the mechanisms in the cochlea that deteriorate with age and chronic noise exposure. Preliminary results suggest that dysfunction in the ion-pumping tissue along the cochlear duct may be responsible for certain types of hearing loss seen with age. Studies are also proposed to examine some effects of age and noise on the second-order neurons in the cochlear nucleus. The purpose of the cochlear nucleus studies is to begin to examine how the central nervous system responds to long-term low-level exposures of noise. The proposed work has direct bearing on human studies concerned with the gradual loss of hearing often found in the elderly, a process termed presbyacusis. Systematic studies in animals under controlled conditions will provide an opportunity to test various hypotheses of how age and environment interact to change the peripheral auditory system.