NON-CONTIGUOUS PATTERNS AND FUNCTIONAL DOMAINS IN DNA

迄今为止，绝大多数可用的序列分析程序是 设计用于允许用户检测出现的连续序列片段 比其他相邻的图案更频繁。然而， 实验证据表明，核酸的特殊功能 片段很少与单一的简单序列基序相关。的 负责生物功能的模式通常是不连续的 并且由几个短的寡核苷酸组成，所述寡核苷酸被可变的 长度和组成。鉴于正在进行的大型测序项目 DNA功能域物理作图的可靠方法将是 无价之宝为了制作可靠的地图，需要可靠的标准， 区分参与不同功能的序列。 非连续模式分析已经提供了大量 区分蛋白质编码基因、内含子和 非法重组位点。据信，通过使用这种 重复DNA中的各种调控区域 序列将被明确地映射。

The vast majority of sequence analysis programs available to date are designed to allow users to detect contiguous sequence fragments that occur more frequently than other contiguous motifs. However, substantial experimental evidence indicates that specific functions of nucleic acids fragments are rarely associated with single, simple sequence motifs. The patterns responsible for biological function are most often non-contiguous and consist of several short oligonucleotides separated by gaps of variable length and composition. In view of the ongoing large sequencing projects reliable procedures for physical mapping of DNA functional domains will be invaluable. To make reliable maps one needs reliable criteria that distinguish between sequences involved in different functions. Non-contiguous pattern analysis already has provided a substantial number of criteria for distinction between protein coding genes, introns, and illegitimate recombination sites. It is believed that by using this methodology various kinds of regulatory regions within repetitive DNA sequences will be mapped unambiguously.