SOMATIC CELL NON-HOMOLOGOUS RECOMBINATION

罕见的DNA重排，不需要扩展的序列相似性 亲本分子)可导致严重的染色体遗传改变 体细胞中的碎片。到目前为止，大约有600个亲本序列 这种交叉是已知的。预计他们的人数将 以每年50-100的速度增长。这个新项目的目的是 将有关非法重组的可用数据存储在一个地方。另一个 目标是为实验分子生物学家提供简单的工具 确定新测序的DNA片段是否包含潜在的重组 不管是不是“热点”。本项目的研究部分涉及到对 已知序列和对非同源性的可能机制的解释 重组。序列分析和分子建模的方法有 到目前为止已经应用过了。

Rare DNA rearrangements that require no extended sequence similarity (of parental molecules) can cause severe genetic alterations of chromosomal fragments in somatic cells. Thus far about 600 parental sequences for this kind of crossing-over are known. It is expected that their number will increase with the rate 50-100 per year. The purpose of this new project is to store available data on illegitimate recombination in one place. Another goal is to provide simple tools for experimental molecular biologists to decide if newly sequenced DNA fragments contain potential recombination 'hot-spots' or not. The research part of this project concerns analysis of known sequences and possible elucidation of mechanisms for non-homologous recombination. Methods of sequence analysis and molecular modeling have been applied thus far.