NON-CONTIGUOUS PATTERNS AND FUNCTIONAL DOMAINS IN DNA

该项目的主要目标是提供一个一致的方法， 在未注释的核酸中定位推定的功能结构域 序列的 研究是从两个方向进行的： 1)通过计算实验确定函数关联序列 在大量功能等同序列的集合中的模式。 2)设计有助于“翻译”观察到的序列模式的协议 转换成可用于映射的判别函数。 一个软件不仅可以绘制基因，还可以绘制各种 非编码区由这些研究产生。 详细的方法 从序列数据中寻找推定的功能结构域的指导原则是 目前正在制定中。 项目编号Z 01 CB 08395-02 LMMB已与本项目合并。 目前对非法重组位点数据库进行了分析 出现显著的非连续模式。 的例程 在未注释的序列中绘制非法重组区域， 准备.

The main goal of this project is to provide a consistent methodology for locating putative functional domains in unannotated nucleic acid sequences. Studies are conducted in two directions: 1) Determine by computational experiments, function-associated sequence patterns in large collections of functionally equivalent sequences. 2) Design protocols that will help "translate" observed sequence patterns into discriminant functions usable for mapping. A software for mapping not only genes but also various kinds of non-coding regions resulted from these studies. Detailed methodological guidelines for finding putative functional domains from sequence data are now being worked out. Project No. Z01 CB 08395-02 LMMB has been converged with this project. The database of illegitimate recombination sites is currently analyzed for the occurrence of significant non-contiguous pattern. A routine to map illegitimate recombination regions in unannotated sequences is now in preparation.