NON-CONTIGUOUS PATTERNS AND FUNCTIONAL DOMAINS IN DNA

DNA 中的非连续模式和功能域

• 批准号: 3808533
• 负责人: A K KONOPKA
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3808533
• 关键词: DNA; computer assisted sequence analysis; genetic mapping; genetic regulatory element; nucleic acid sequence

The main goal of this project is to provide a consistent methodology for locating putative functional domains in unannotated nucleic acid sequences. Studies are conducted in two directions: 1) Determine by computational experiments, function-associated sequence patterns in large collections of functionally equivalent sequences. 2) Design protocols that will help "translate" observed sequence patterns into discriminant functions usable for mapping. A software for mapping not only genes but also various kinds of non-coding regions resulted from these studies. Detailed methodological guidelines for finding putative functional domains from sequence data are now being worked out. Project No. Z01 CB 08395-02 LMMB has been converged with this project. The database of illegitimate recombination sites is currently analyzed for the occurrence of significant non-contiguous pattern. A routine to map illegitimate recombination regions in unannotated sequences is now in preparation.

这个项目的主要目标是为以下方面提供一致的方法