TEACHING NURSING HOME

这项建议要求支持继续教学护理学 HOME，一个多地点、多机构的项目。这 TNH代表了与老年病相关的资源重组 研究一种跨越机构、 部门和纪律界限。参与组织 包括：蒙特菲奥雷阿尔伯特·爱因斯坦医学院 医疗中心和他们的四个相关的长期护理 设施，以及Mt.圣文森特护理计划。 五个研究协议围绕一个强大的服务进行组织 核心，其中包括共同课题库、共享评估 人员、共享评估、共享数据库、共享数据 管理和分析，以及共同的神经病理学相关性。 五个组成部分的研究项目研究：痴呆症， 骨关节炎、运动控制障碍、年龄相关记忆 损害和充血性心力衰竭，包括临床和 实验室调查。 到未来五年结束时，我们应该已经开发出一种 关于1000多个研究主题的全面数据库和： 1)确定病史、神经检查中的哪些因素， 神经心理特征、神经成像或生化 标记物提高了阿尔茨海默病(AD)的诊断准确性， 评估区分AD和AD的病理标准 2)描述正常老年人的步态和平衡； 描述了跌倒的自然历史；确定了 以及明确的运动控制的病理生理学机制 和干预的含义；3)确定的生物标记 在滑液中，并描述了骨性关节炎的光谱 有共同投诉的人；4)描绘了年龄综合征- 相关记忆损害及其过程，以及5)阐明 一组老年人中的充血性心力衰竭综合征。在……里面 简而言之，我们将对以下条件进行研究 严重影响老年人的生活质量，而这 该项目有望对老年医学产生重要影响 多练习，多关心。

This proposal requests support to continue the Teaching Nursing Home, a multi-site, multi-institutional program project. This TNH represents a reorganization of resources relating to geriatric research into a structure which crosses institutional, departmental and disciplinary lines. Participating organizations include: the Albert Einstein College of Medicine, Montefiore Medical Center, and their four associated long term care facilities, and the College of Mt. St. Vincent Nursing Program. Five research protocols are organized around a strong service core, which includes a common subject pool, shared assessment personnel, shared assessments, a shared database, shared data management and analysis, and shared neuropathologic correlation. The five component research projects study: dementia, osteoarthritis, motor-control impairment, age-associated memory impairment, and congestive heart failure, and include clinical and laboratory investigations. By the end of the next five years, we should have developed a comprehensive database on more than 1000 research subjects and: 1) determined which factors in history, neurologic exam, neuropsychological profile, neuro-imaging, or biochemical markers improve diagnostic accuracy in Alzheimer's disease (AD), and evaluated pathological criteria which differentiate AD from normal aging; 2) described gait and balance in normal elderly; described the natural history of fallers; identified predictors of falling; and defined pathophysiologic mechanisms of motor control and implications for intervention; 3) identified biological markers in synovial fluid and described Osteoarthritis in a spectrum of persons with joint complaints; 4) delineated the syndrome of Age- Associated Memory Impairment and its course, and 5) clarified the syndrome of congestive heart failure in a cohort of old . In short, we will have conducted research on conditions which severely affect the quality of life of older persons, and this project will, hopefully, have an important impact on geriatric practice and care.