PATHOPHYSIOLOGIC, BIOCHEMICAL CHANGES OF THERMAL INJURY

液体和电解质易位机制的研究， 红细胞破坏、心脏（高和低）功能和鉴定 免疫球蛋白抑制物质的严重烧伤后， 进行。 跨膜电位（TM）和微肌电解质的系列测量 分析加上代谢平衡的研究是在热损伤 受伤超过全身表面积（TBSA）35%的患者。 方法 正在开发用于快速测定可交换钠质量， 用于研究电解质转运机制的动物模型 异常 红细胞破坏已被确定为由有毒物质引起的。 游离脂肪酸水平和脂肪代谢研究开始。 目前 脂蛋白代谢和肝脏代谢的动员脂肪正在被 通过开发用于氧化研究的三室模型， 高密度脂蛋白代谢与肝细胞培养的作用 肉毒碱和HMG-Ac活性。 豚鼠TBSA烧伤40%， 已开发用于心肌异常的未来研究， 营养和脂肪代谢的治疗干预。 纯化 已经完成了色谱技术用于分离 α-球蛋白相关的免疫抑制因子， 在淋巴细胞和白细胞体外模型上进行测试。

Studies of the mechanisms of fluid and electrolyte translocation, protracted erythrocyte destruction, cardiac (hyper- and hypo-) function and identification of immunoglobulin-suppressive substance following major burn injury are being undertaken. Serial measurements of transmembrane potentials (TM) and micromuscle electrolyte analysis coupled with metabolic balance studies are done in thermally injured patients with injuries exceeding 35% total body surface area (TBSA). Methods are being developed for rapid determination of exchangeable sodium mass and animal models developed for study of the mechanism of electolyte transport abnormalities. Erythrocyte destruction has been identified as produced by toxic levels of free fatty acids and studies of fat metabolism initiated. Currently lipoprotein metabolism and liver metabolism of mobilized adipose is being pursued by the development of a three compartment model for oxidation studies of high density lipoprotein metabolism and hepatcyte culture for the role of carnitine and HMG-Ac activity. Forty percent TBSA scald burn in guina pigs have been developed for the future study of the myocardial abnormalities and therapeutic interventions in nutrition and metabolism of fat. Purification chromatography techniques have been accomplished for the isolation of alpha-globulin associated immunosuppressive factors which are currently being tested on a lymphocyte and leukocyte in vitro model.