Deciphering mechanisms underlying breast cancer to improve patient outcomes

乳腺癌是一种异质性很强的疾病。患者通常采用“一刀切”的治疗方法，但对治疗的反应仍然不同。为了更有效地个性化治疗，迫切需要确定精确的细胞类型，并启动导致乳腺癌的遗传事件。这一应用集中在了解乳腺癌发生和发展的机制，具有识别新的预后标志物和治疗靶点的潜力。

Breast cancer is a highly heterogeneous disease. Patients are often treated in a ‘one size fits all’ approach, but response to therapy remains disparate. To more effectively personalise therapy, there is a pressing need to define the precise cell types and initiating genetic events that give rise to breast cancer. This application is centred on understanding mechanisms of breast cancer initiation and progression, with the potential of identifying new prognostic markers and therapeutic targets.