RELATIONSHIP OF CERVICAL INTRAEPITHELIAL NEOPLASIA III AND HPV

本研究的目的是：1）确定HPV类型 与宫颈癌前病变相关， 上皮内瘤变III（CIN III），也称为上皮内癌， （2）确定是否存在和可能参与 其他感染因子，如HSV-II、CMV和衣原体;以及 3)为了确定其他暴露的影响，如吸烟， 避孕方法（口服避孕药）和营养。 这 一项基于人群的病例对照研究将确定45岁的女性 老年人或更少的群体健康合作社的国王县，其中一个 美国最大的HMO，新诊断的CIN 1986年10月至1991年3月。 我们计划找出 通过病理科的病例组健康 和癌症监测系统，一个基于人群的癌症监测系统， 注册表 我们估计可以采访到 约350例原位癌（CIN III）。 的 对照组将由大约350名妇女组成， 年龄和居住地相同的人， 团体健康的注册文件。 所有既往细胞学检查 将收集病例和对照样本并进行评价 通过原位杂交检测HPV的存在， 细胞学特征 所有病例的组织学标本将 也可以测试特定的HPV类型，HSV-II和CMV。 数据 并将采集血液。

The purposes of this study will be 1) to determine the HPV types associated with pre-cancerous cervical lesions, cervical intraepithelial neoplasia III (CIN III), also called carcinoma-in- situ; 2) to determine the presence and possible involvement of other infectious agents, such as HSV-II, CMV, and chlamydia; and 3) to ascertain the effect of other exposures, such as smoking, contraceptive method (oral contraceptives), and nutrition. This population-based case-control study will identify women 45 years old or less in Group Health Cooperative of King County, one of the largest HMOs in the United States, with newly diagnosed CIN III from October, 1986 through March, 1991. We plan to identify the cases through the Pathology Department of Group Health and the Cancer Surveillance System, a population-based cancer registry. We estimate we will be able to interview approximately 350 cases of carcinoma-in-situ (CIN III). The control group will consist of approximately 350 women of the same ages and county of residence who are identified through the enrollment files of Group Health. All previous cytologic specimens of cases and controls will be collected and evaluated for the presence of HPV by means of in-situ hybridization and cytologic features. The histologic specimens of all cases will also be tested for specific HPV types, HSV-II, and CMV. Data from an in-person interview and blood will also be collected.