MULTIPURPOSE ARTHRITIS CENTER

北方大学多功能关节炎中心 教堂山的卡罗莱纳由一项生物医学研究组成 非生物医学研究组成部分，免疫学核心， 一个是数值科学核心，另一个是管理核心。范围： 生物医学部分的重点包括：分子 系统性红斑狼疮及相关疾病自身抗体的功能研究 疾病；自身免疫小鼠模型的基本机制； 类风湿因子等的遗传学和独特型 自身抗体；MHC的分子生物学；特征 关于细胞激活抗原；结构和细胞生物学 补体受体；B细胞分化；补体和 疾病；对胶原蛋白的自身免疫：细菌细胞壁 作为侵蚀性滑膜炎的触发剂和活化剂的成分；以及 癌基因和自身免疫。五个发展性和可行性 提出了项目建议。四个是分子生物学/遗传学 对自身免疫或炎症的基本问题的研究。 第五，将测试开发一部小说和 可能有用的猴子反应性关节炎新模型。 在教育和社区活动方面建立了坚实的基础， 非生物医学研究部分提出了六个项目。二 项目的重点是风湿病医科学生的教育- 奥奇。两个项目是基于行为理论的调查 关节炎患者，延续了社交和 这一部分的行为研究。其中一个项目检查了 医生和患者的临床接触，目标是 改善医患沟通。期末专题 关注南方农村社区的关节炎工作残疾， 反映了对以社区为基础的流行病学的主要关注 研究。已经资助的实验室研究将由 免疫学核心，将发展和维持免疫学 和科学数据库，生产单抗，支持 高效液相设备，提供流式细胞术，并保持病原体- 自由近亲繁殖的小鼠群体。一个数字科学核心将支持 在非生物医学组成部分方面的研究努力 研究设计和方法、数据收集、项目 参与者登记、数据处理、数据库管理和 数据分析。行政核心将提供全面的 协调和支持MAC活动，执行内部工作 审查并确保大学内部和 社区。

The Multipurpose Arthritis Center at the University of North Carolina in Chapel Hill consists of a Biomedical Research Component, a Non-Biomedical Research Component, an Immunology Core, a Numerical Sciences Core, and an Administrative Core. Areas of special emphasis in the Biomedical Component include: molecular and functional studies of autoantibodies in SLE and related diseases; basic mechanisms in murine models of autoimmunity; the genetics and idiotypy of rheumatoid factor and other autoantibodies; the molecular biology of the MHC; characterization of cellular activation antigens; the structure and cell biology of complement receptors; B cell differentiation; complement and disease; autoimmunity to collagen: bacterial cell wall constituents as triggers and activators of erosive synovitis; and oncogenes and autoimmunity. Five Developmental and Feasibility projects are proposed. Four are molecular biology/genetic investigations of basic questions in autoimmunity or inflammation. The fifth will test the feasibility of developing a novel and potentially useful new model of reactive arthritis in monkeys. Building upon a strong base in education and community activities, the Non-Biomedical Research Component proposes six projects. Two projects focus on the education of medical students in rheumatol- ogy. Two projects are behavioral theory-based investigations of patients with arthritis, continuing a tradition of social and behavioral research in this Component. One project examines the clinical encounter between physicians and patients, with the goal of improving patient-doctor communication. The final project concerns arthritis work disability in a rural southern community, and reflects a major focus on community-based epidemiological research. Already-funded laboratory research will be supported by an Immunology Core, which will develop and maintain immunological and scientific databases, produce monoclonal antibodies, support a HPLC facility, provide flow cytometry, and maintain a pathogen- free inbred mouse colony. A Numerical Sciences Core will support research efforts in the Non-Biomedical Component with respect to research design and methodology, data collection, project participant registry, data processing, database management, and data analysis. The Administrative Core will provide overall coordination and support of MAC activities, perform internal review, and assure optimum liaison within the University and in the community.