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ANTIGENIC ANALYSIS OF SEXUAL STAGES OF MALARIA PARASITES

ANTIGENIC ANALYSIS OF SEXUAL STAGES OF MALARIA PARASITES
疟疾寄生虫性阶段的抗原分析
批准号：
3822002
负责人：
R CARTER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3822002
关键词：
Plasmodium Plasmodium falciparum antimicroorganism antibody arthropod borne communicable disease blocking antibody cellular immunity communicable disease transmission early embryonic stage genetic manipulation germ cells host organism interaction human tissue immunochemistry malaria microorganism culture microorganism immunology microorganism reproduction molecular cloning monoclonal antibody nonmammalian vertebrate embryology nucleic acid sequence oligonucleotides protozoal antigen

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中文摘要
翻译
识别配子和动合子蛋白并克隆基因 编码这些蛋白抗原，这些蛋白抗原是 阻断配子体对蚊子的感染性的抗体。 免疫的蛋白质靶点将用单克隆抗体鉴定。 抗体的 克隆将取决于目标的纯化 抗原与单克隆抗体和微测序 从这些蛋白质中提取消化酶片段， 寡核苷酸探针。
英文摘要
Identify gamete and ookinete proteins and clone the genes encoding these protein antigens which are the targets of antibodies blocking infectivity of gametocytes to mosquitoes. Protein targets of immunity will be identified with monoclonal antibodies. The cloning will depend on purification of target antigens with monoclonal antibodies and the microsequencing of peptic fragments from these proteins in order to make oligonucleotide probes.
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CULTURE PHYSIOLOGY AND ANTIGENIC ANALYSIS OF SEXUAL STAGES OF MALARIA PARASITES
ANTIGENIC ANALYSIS OF SEXUAL STAGES OF MALARIA PARASITES
CULTURE PHYSIOLOGY AND ANTIGENIC ANALYSIS OF SEXUAL STAGES OF MALARIA PARASITES
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