Deciphering the role of DNA methylation in the regulation of alternative splicing

当一个基因被打开时，信使RNA必须被正确加工以产生功能蛋白质。这种“剪接”过程对于正常的细胞活动是必不可少的，并且在许多人类疾病中被破坏。我们已经发现，表观遗传修饰，DNA甲基化（mC），可以控制剪接。该项目将研究mC如何影响剪接，并使用新的表观基因组编辑工具来控制它，以最终了解和治疗涉及异常剪接的疾病。

When a gene is turned on, the messenger RNA must be correctly processed to generate functional proteins. This ‘splicing’ process is essential for normal cellular activity, and is disrupted in many human diseases. We have discovered that an epigenetic modification, DNA methylation (mC), may control splicing. This project will investigate how mC influences splicing and use new epigenome-editing tools to control it, in order to ultimately understand and treat diseases involving aberrant splicing.